Homo sapiens Gene: IL17RD
Summary
InnateDB Gene IDBG-41013.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IL17RD
Gene Name interleukin 17 receptor D
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000144730
Encoded Proteins
interleukin 17 receptor D
interleukin 17 receptor D
interleukin 17 receptor D
interleukin 17 receptor D
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
[Mus musculus] Intracellular Sef/IL-17R (SEFIR) domain of Il17rd targets TIR adaptor proteins Myd88, Tirap, Ticam1, Ticam2 and Traf6 to inhibit TLR downstream signalling.
Entrez Gene
Summary This gene encodes a membrane protein belonging to the interleukin-17 receptor (IL-17R) protein family. The encoded protein is a component of the interleukin-17 receptor signaling complex, and the interaction between this protein and IL-17R does not require the interleukin (PMID: 19079364). The gene product also affects fibroblast growth factor signaling, inhibiting or stimulating growth through MAPK/ERK signaling (PMID: 21663947, 18096367). [provided by RefSeq, Nov 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:57089982-57170306
Strand Reverse strand
Band p14.3
Transcripts
ENST00000320057 ENSP00000322250
ENST00000296318 ENSP00000296318
ENST00000463523 ENSP00000417516
ENST00000469841
ENST00000467210 ENSP00000418368
ENST00000479825
ENST00000498471
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0007165 signal transduction
Cellular Component
GO:0000139 Golgi membrane
GO:0005634 nucleus
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
EGFR1 pathway
REACTOME
KEGG
INOH
PID BIOCARTA
PID NCI
FGF signaling pathway
Cross-References
SwissProt Q8NFM7
TrEMBL C9J6R0
UniProt Splice Variant
Entrez Gene 54756
UniGene Hs.150725
RefSeq NM_017563 XM_005265238 XM_006713209
HUGO HGNC:17616
OMIM 606807
CCDS CCDS2880
HPRD
IMGT
EMBL AC097358 AF458067 AF494208 AF494211 AL133097 AL833913 AY358774 AY489047 BC111702
GenPept AAI11703 AAM74077 AAM74080 AAM77571 AAQ89134 AAS15051 CAB61408 CAD38769
RNA Seq Atlas 54756