Homo sapiens Gene: TGM3
Summary
InnateDB Gene IDBG-41095.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TGM3
Gene Name transglutaminase 3 (E polypeptide, protein-glutamine-gamma-glutamyltransferase)
Synonyms TGE;
Species Homo sapiens
Ensembl Gene ENSG00000125780
Encoded Proteins
transglutaminase 3 (E polypeptide, protein-glutamine-gamma-glutamyltransferase)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Transglutaminases are enzymes that catalyze the crosslinking of proteins by epsilon-gamma glutamyl lysine isopeptide bonds. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene consists of two polypeptide chains activated from a single precursor protein by proteolysis. The encoded protein is involved the later stages of cell envelope formation in the epidermis and hair follicle. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 20:2296001-2341078
Strand Forward strand
Band p13
Transcripts
ENST00000381458 ENSP00000370867
ENST00000463090
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
Experimentally validated
Total 11 [view]
Protein-Protein 10 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003810 protein-glutamine gamma-glutamyltransferase activity
GO:0003824 catalytic activity
GO:0005509 calcium ion binding
GO:0016746 transferase activity, transferring acyl groups
Biological Process
GO:0006464 cellular protein modification process
GO:0018149 peptide cross-linking
GO:0030216 keratinocyte differentiation
GO:0031069 hair follicle morphogenesis
GO:0031424 keratinization
GO:0043163 cell envelope organization
GO:0051262 protein tetramerization
Cellular Component
GO:0005737 cytoplasm
GO:0031234 extrinsic component of cytoplasmic side of plasma membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt Q08188
TrEMBL
UniProt Splice Variant
Entrez Gene 7053
UniGene Hs.2022
RefSeq NM_003245 XM_006723615
HUGO HGNC:11779
OMIM 600238
CCDS CCDS33435
HPRD
IMGT
EMBL AK290324 AK291351 AK315236 AL031678 BC109075 BC109076 CH471133 EF102483 L10386
GenPept AAA61155 AAI09076 AAI09077 ABK41960 BAF83013 BAF84040 BAG37663 CAB37633 EAX10601 EAX10602
RNA Seq Atlas 7053