Version 5.4
Homo sapiens Gene: DNASE1L3
Summary
InnateDB Gene IDBG-42007.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DNASE1L3
Gene Name deoxyribonuclease I-like 3
Synonyms DHP2; DNAS1L3; LSD; SLEB16
Species Homo sapiens
Ensembl Gene ENSG00000163687
Encoded Proteins
IDBP-241356
deoxyribonuclease I-like 3
IDBP-485468
deoxyribonuclease I-like 3
IDBP-476928
deoxyribonuclease I-like 3
IDBP-477262
deoxyribonuclease I-like 3
IDBP-477276
deoxyribonuclease I-like 3
IDBP-484486
deoxyribonuclease I-like 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the deoxyribonuclease I family. The encoded protein hydrolyzes DNA, is not inhibited by actin, and mediates the breakdown of DNA during apoptosis. Mutations in this gene are a cause of systemic lupus erythematosus-16. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:58192257-58214697
Strand Reverse strand
Band p14.3
Transcripts
ENST00000394549 ENSP00000378053
ENST00000486455 ENSP00000419052
ENST00000483681 ENSP00000417047
ENST00000477209 ENSP00000417976
ENST00000461914 ENSP00000418113
ENST00000460422 ENSP00000418509
ENST00000463694
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0004519 endonuclease activity
GO:0004520 endodeoxyribonuclease activity
GO:0004536 deoxyribonuclease activity
GO:0005509 calcium ion binding
GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters
Biological Process
GO:0000737 DNA catabolic process, endonucleolytic
GO:0006259 DNA metabolic process
GO:0006308 DNA catabolic process
GO:0006309 apoptotic DNA fragmentation
GO:0010623 developmental programmed cell death
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000025279
View Gene Order
ENSBTAG00000018294
Not yet available
Cross-References
SwissProt
TrEMBL C9J0L2
UniProt Splice Variant
Entrez Gene 1776
UniGene Hs.476453
RefSeq NM_001256560 NM_004944
HUGO HGNC:2959
OMIM 602244
CCDS CCDS2886 CCDS58836
HPRD 03764
IMGT
EMBL AC137936
GenPept
RNA Seq Atlas 1776

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca