Version 5.4
Homo sapiens Gene: GUCY1A3
Summary
InnateDB Gene IDBG-42375.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GUCY1A3
Gene Name guanylate cyclase 1, soluble, alpha 3
Synonyms GC-SA3; GUC1A3; GUCA3; GUCSA3; GUCY1A1; MYMY6
Species Homo sapiens
Ensembl Gene ENSG00000164116
Encoded Proteins
IDBP-42379
guanylate cyclase 1, soluble, alpha 3
IDBP-242827
guanylate cyclase 1, soluble, alpha 3
IDBP-379170
guanylate cyclase 1, soluble, alpha 3
IDBP-379171
guanylate cyclase 1, soluble, alpha 3
IDBP-476892
guanylate cyclase 1, soluble, alpha 3
IDBP-473667
guanylate cyclase 1, soluble, alpha 3
IDBP-474646
guanylate cyclase 1, soluble, alpha 3
IDBP-480095
guanylate cyclase 1, soluble, alpha 3
IDBP-473560
guanylate cyclase 1, soluble, alpha 3
IDBP-481598
guanylate cyclase 1, soluble, alpha 3
IDBP-809745
guanylate cyclase 1, soluble, alpha 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Soluble guanylate cyclases are heterodimeric proteins that catalyze the conversion of GTP to 3',5'-cyclic GMP and pyrophosphate. The protein encoded by this gene is an alpha subunit of this complex and it interacts with a beta subunit to form the guanylate cyclase enzyme, which is activated by nitric oxide. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
Soluble guanylate cyclases are heterodimeric proteins that catalyze the conversion of GTP to 3\',5\'-cyclic GMP and pyrophosphate. The protein encoded by this gene is an alpha subunit of this complex and it interacts with a beta subunit to form the guanylate cyclase enzyme, which is activated by nitric oxide. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:155666711-155732349
Strand Forward strand
Band q32.1
Transcripts
ENST00000296518 ENSP00000296518
ENST00000393832 ENSP00000377418
ENST00000455639 ENSP00000412201
ENST00000443668 ENSP00000409903
ENST00000506455 ENSP00000424361
ENST00000511108 ENSP00000421493
ENST00000512983
ENST00000511507 ENSP00000426968
ENST00000515602
ENST00000509901 ENSP00000424863
ENST00000515201 ENSP00000422141
ENST00000513574 ENSP00000426040
ENST00000621234 ENSP00000479710
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 4 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0004383 guanylate cyclase activity
GO:0004872 receptor activity
GO:0005525 GTP binding
GO:0016849 phosphorus-oxygen lyase activity
GO:0020037 heme binding
Biological Process
GO:0006182 cGMP biosynthetic process
GO:0007263 nitric oxide mediated signal transduction
GO:0007596 blood coagulation
GO:0008015 blood circulation
GO:0008217 regulation of blood pressure
GO:0009190 cyclic nucleotide biosynthetic process
GO:0030828 positive regulation of cGMP biosynthetic process
GO:0035556 intracellular signal transduction
GO:0052565 response to defense-related host nitric oxide production
GO:0060087 relaxation of vascular smooth muscle
Cellular Component
GO:0008074 guanylate cyclase complex, soluble
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000033910
View Gene Order
ENSBTAG00000014576
Not yet available
Pathways
NETPATH
REACTOME
REACT_23862
Nitric oxide stimulates guanylate cyclase pathway
REACT_23876
Platelet homeostasis pathway
REACT_604
Hemostasis pathway
KEGG
hsa04540
Gap junction pathway
hsa00230
Purine metabolism pathway
hsa04730
Long-term depression pathway
hsa04270
Vascular smooth muscle contraction pathway
hsa04970
Salivary secretion pathway
INOH
INOH website
Purine nucleotides nucleosides metabolism pathway
PID NCI
Cross-References
SwissProt Q02108
TrEMBL J3KPQ8 Q9NNW8
UniProt Splice Variant
Entrez Gene 2982
UniGene Hs.24258 Hs.623143
RefSeq NM_000856 NM_001130682 NM_001130683 NM_001130684 NM_001130685 NM_001130687 NM_001256449 XM_005262955 XM_005262956 XM_005262957 XM_006714196 XM_006714197 XM_006714198
HUGO HGNC:4685
OMIM 139396
CCDS CCDS34085 CCDS54812
HPRD 00768
IMGT
EMBL AC104083 AH009232 AK309950 BC028384 CH471056 U58855 X66534 Y15723
GenPept AAB94794 AAF64043 AAH28384 CAA47145 CAA75738 EAX04892 EAX04895 EAX04896 EAX04897
RNA Seq Atlas 2982

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca