Version 5.4
Homo sapiens Gene: CPE
Summary
InnateDB Gene IDBG-43626.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CPE
Gene Name carboxypeptidase E
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000109472
Encoded Proteins
IDBP-295117
carboxypeptidase E
IDBP-379509
carboxypeptidase E
IDBP-480085
carboxypeptidase E
IDBP-483505
carboxypeptidase E
IDBP-477876
carboxypeptidase E
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a carboxypeptidase that cleaves C-terminal amino acid residues and is involved in the biosynthesis of peptide hormones and neurotransmitters, including insulin. It is a peripheral membrane protein. The protein specifically binds regulated secretory pathway proteins, including prohormones, but not constitutively secreted proteins. Mutations in this gene are implicated in type II diabetes. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:165361194-165498320
Strand Forward strand
Band q32.3
Transcripts
ENST00000402744 ENSP00000386104
ENST00000431967 ENSP00000416601
ENST00000513982 ENSP00000424830
ENST00000480404 ENSP00000427629
ENST00000511992 ENSP00000423699
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 12 [view]
Protein-Protein 12 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004180 carboxypeptidase activity
GO:0004181 metallocarboxypeptidase activity
GO:0008270 zinc ion binding
GO:0042043 neurexin family protein binding
GO:0050839 cell adhesion molecule binding
Biological Process
GO:0003214 cardiac left ventricle morphogenesis
GO:0006464 cellular protein modification process
GO:0006508 proteolysis
GO:0007218 neuropeptide signaling pathway
GO:0008152 metabolic process
GO:0030070 insulin processing
GO:0044267 cellular protein metabolic process
GO:0072657 protein localization to membrane
Cellular Component
GO:0005634 nucleus
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0030658 transport vesicle membrane
GO:0030667 secretory granule membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000037852
View Gene Order
ENSBTAG00000016514
Not yet available
Pathways
NETPATH
REACTOME
REACT_15550
Insulin processing pathway
REACT_17015
Metabolism of proteins pathway
REACT_160078
Peptide hormone metabolism pathway
KEGG
hsa04940
Type I diabetes mellitus pathway
INOH
PID NCI
arf6_traffickingpathway
Arf6 trafficking events
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.733246 Hs.75360
RefSeq NM_001873
HUGO
OMIM
CCDS CCDS3810
HPRD 00272
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca