Version 5.4
Homo sapiens Gene: RASGRP3
Summary
InnateDB Gene IDBG-43993.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RASGRP3
Gene Name RAS guanyl releasing protein 3 (calcium and DAG-regulated)
Synonyms GRP3
Species Homo sapiens
Ensembl Gene ENSG00000152689
Encoded Proteins
IDBP-294138
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
IDBP-294134
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
IDBP-294131
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
IDBP-372168
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
IDBP-372171
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
IDBP-372173
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
IDBP-372174
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
IDBP-372176
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
IDBP-372180
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Members of the RAS (see HRAS; MIM 190020) subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RASGRP3, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000 [PubMed 10934204]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:33436324-33564750
Strand Forward strand
Band p22.3
Transcripts
ENST00000402538 ENSP00000385886
ENST00000403687 ENSP00000384192
ENST00000407811 ENSP00000383917
ENST00000437184 ENSP00000393866
ENST00000442390 ENSP00000405648
ENST00000423159 ENSP00000388139
ENST00000444784 ENSP00000400602
ENST00000425210 ENSP00000401974
ENST00000419772 ENSP00000409593
ENST00000484909
ENST00000497723
ENST00000479528
ENST00000482857
ENST00000494927
ENST00000477927
ENST00000490150
ENST00000468856
ENST00000482731
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
Experimentally validated
Total 12 [view]
Protein-Protein 12 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004871 signal transducer activity
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005088 Ras guanyl-nucleotide exchange factor activity
GO:0005509 calcium ion binding
GO:0017016 Ras GTPase binding
GO:0019900 kinase binding
GO:0019992 diacylglycerol binding
GO:0046582 Rap GTPase activator activity
Biological Process
GO:0000165 MAPK cascade
GO:0007264 small GTPase mediated signal transduction
GO:0007265 Ras protein signal transduction
GO:0032854 positive regulation of Rap GTPase activity
GO:0035556 intracellular signal transduction
GO:0043087 regulation of GTPase activity
GO:0043547 positive regulation of GTPase activity
GO:0051056 regulation of small GTPase mediated signal transduction
Cellular Component
GO:0005622 intracellular
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0032045 guanyl-nucleotide exchange factor complex
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000071042
View Gene Order
ENSBTAG00000008006
Not yet available
Pathways
NETPATH
NetPath_12
BCR pathway
REACTOME
REACT_118778
Activation of RAS in B cells pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_118773
Signaling by the B Cell Receptor (BCR) pathway
REACT_118638
Downstream signaling events of B Cell Receptor (BCR) pathway
KEGG
hsa04010
MAPK signaling pathway pathway
hsa04662
B cell receptor signaling pathway pathway
INOH
PID NCI
ras_pathway
Regulation of Ras family activation
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.143674 Hs.603716
RefSeq NM_001139488 NM_015376 NM_170672 XM_005264246 XM_005264247
HUGO
OMIM
CCDS CCDS46256 CCDS54346
HPRD 15213
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca