Homo sapiens Gene: CD22
Summary
InnateDB Gene IDBG-44001.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CD22
Gene Name CD22 molecule
Synonyms SIGLEC-2; SIGLEC2;
Species Homo sapiens
Ensembl Gene ENSG00000012124
Encoded Proteins
CD22 molecule
CD22 molecule
CD22 molecule
CD22 molecule
CD22 molecule
CD22 molecule
CD22 molecule
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
CD22 (Siglec-2), like other sialic acid-binding immunoglobulin-like lectins (siglecs), is predominately expressed on immune cells. CD22 exhibits hallmarks of clathrin-mediated endocytosis and traffics to recycling compartment, reflecting its role in cell signalling and innate immunity.
CD22 expression and function are differentially regulated in B-1 and conventional B-2 cells, which are implicated in innate and adaptive immunity, respectively.
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 19:35319261-35347355
Strand Forward strand
Band q13.12
Transcripts
ENST00000085219 ENSP00000085219
ENST00000270311 ENSP00000270311
ENST00000341773 ENSP00000339349
ENST00000419549 ENSP00000403822
ENST00000536635 ENSP00000442279
ENST00000544992 ENSP00000441237
ENST00000593867 ENSP00000471972
ENST00000600655
ENST00000598028
ENST00000599811 ENSP00000469523
ENST00000594250 ENSP00000469984
ENST00000600424 ENSP00000471399
ENST00000594349 ENSP00000470724
ENST00000601414
ENST00000600131 ENSP00000469503
ENST00000597916 ENSP00000472762
ENST00000600905
ENST00000599799
ENST00000595780 ENSP00000472664
ENST00000601329
ENST00000599717 ENSP00000470681
ENST00000602123
ENST00000598138
ENST00000595419
ENST00000593704
ENST00000597433
ENST00000601769 ENSP00000470193
ENST00000598815
ENST00000594954
ENST00000596492
ENST00000598537 ENSP00000469980
ENST00000602224
ENST00000601732
ENST00000594125 ENSP00000473221
ENST00000613136 ENSP00000482823
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
Experimentally validated
Total 18 [view]
Protein-Protein 18 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 11 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0007155 cell adhesion
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0005887 integral component of plasma membrane
GO:0009897 external side of plasma membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
BCR pathway
REACTOME
KEGG
Cell adhesion molecules (CAMs) pathway
Hematopoietic cell lineage pathway
B cell receptor signaling pathway pathway
INOH
PID BIOCARTA
PID NCI
BCR signaling pathway
Cross-References
SwissProt P20273
TrEMBL M0QYP4 M0R1M2 M0R2M0 M0R3H1 Q0EAF5 Q9UQB1 Q9UQB2
UniProt Splice Variant
Entrez Gene 933
UniGene Hs.579691
RefSeq NM_001771 NM_001185099 NM_001185100 NM_001278417 NM_001185101
HUGO HGNC:1643
OMIM 107266
CCDS CCDS12457 CCDS54248 CCDS54247 CCDS62634 CCDS54249
HPRD 00114
IMGT
EMBL AB012995 AB012996 AB012997 AB012998 AB012999 AB013000 AB013002 AB013003 AB013004 AB013005 AB013006 AB013007 AB253793 AB253794 AB253795 AC002132 AK225625 BC109306 EF064756 U62631 X52785 X59350
GenPept AAB06448 AAB06449 AAI09307 ABK41939 BAA36564 BAA36565 BAA36566 BAA36567 BAA36568 BAA36569 BAA36571 BAA36572 BAA36573 BAA36574 BAA36575 BAA36576 BAF32756 BAF32757 BAF32758 CAA36988 CAA42006
RNA Seq Atlas 933