Version 5.4
Homo sapiens Gene: BRAF
Summary
InnateDB Gene IDBG-44351.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BRAF
Gene Name v-raf murine sarcoma viral oncogene homolog B1
Synonyms B-RAF1; BRAF1; NS7; RAFB1;
Species Homo sapiens
Ensembl Gene ENSG00000157764
Encoded Proteins
IDBP-44353
v-raf murine sarcoma viral oncogene homolog B1
IDBP-484046
v-raf murine sarcoma viral oncogene homolog B1
IDBP-473496
v-raf murine sarcoma viral oncogene homolog B1
IDBP-485293
v-raf murine sarcoma viral oncogene homolog B1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein belonging to the raf/mil family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERKs signaling pathway, which affects cell division, differentiation, and secretion. Mutations in this gene are associated with cardiofaciocutaneous syndrome, a disease characterized by heart defects, mental retardation and a distinctive facial appearance. Mutations in this gene have also been associated with various cancers, including non-Hodgkin lymphoma, colorectal cancer, malignant melanoma, thyroid carcinoma, non-small cell lung carcinoma, and adenocarcinoma of lung. A pseudogene, which is located on chromosome X, has been identified for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:140719327-140924764
Strand Reverse strand
Band q34
Transcripts
ENST00000288602 ENSP00000288602
ENST00000496384 ENSP00000419060
ENST00000479537 ENSP00000418033
ENST00000497784 ENSP00000420119
ENST00000469930
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 70 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated
Total 70 [view]
Protein-Protein 69 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004709 MAP kinase kinase kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005057 receptor signaling protein activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0031434 mitogen-activated protein kinase kinase binding
GO:0042802 identical protein binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0000165 MAPK cascade
GO:0000186 activation of MAPKK activity
GO:0002318 myeloid progenitor cell differentiation
GO:0006468 protein phosphorylation
GO:0007165 signal transduction
GO:0007264 small GTPase mediated signal transduction
GO:0007268 synaptic transmission
GO:0008542 visual learning
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0009887 organ morphogenesis
GO:0010628 positive regulation of gene expression
GO:0010764 negative regulation of fibroblast migration
GO:0030154 cell differentiation
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0035019 somatic stem cell maintenance
GO:0035556 intracellular signal transduction
GO:0035690 cellular response to drug
GO:0042127 regulation of cell proliferation
GO:0043066 negative regulation of apoptotic process
GO:0043367 CD4-positive, alpha-beta T cell differentiation
GO:0043368 positive T cell selection
GO:0043434 response to peptide hormone
GO:0043524 negative regulation of neuron apoptotic process
GO:0046632 alpha-beta T cell differentiation
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0051291 protein heterooligomerization
GO:0051496 positive regulation of stress fiber assembly
GO:0051591 response to cAMP
GO:0060291 long-term synaptic potentiation
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0070849 response to epidermal growth factor
GO:0071277 cellular response to calcium ion
GO:1900026 positive regulation of substrate adhesion-dependent cell spreading
GO:2000301 negative regulation of synaptic vesicle exocytosis
GO:2000352 negative regulation of endothelial cell apoptotic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0043005 neuron projection
GO:0044297 cell body
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
ENSMUSG00000002413
View Gene Order
Ortholuge
SSD Ortholog
Ortholog supports species divergence
ENSBTAG00000021761
Not yet available
Ortholuge
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
NetPath_4
EGFR1 pathway
NetPath_12
BCR pathway
NetPath_56
Prolactin pathway
REACTOME
REACT_120736
Signaling by FGFR in disease pathway
REACT_11061
Signalling by NGF pathway
REACT_12077
Signalling to p38 via RIT and RIN pathway
REACT_13685
Neuronal System pathway
REACT_12076
Frs2-mediated activation pathway
REACT_111080
Spry regulation of FGF signaling pathway
REACT_111102
Signal Transduction pathway
REACT_20593
Post NMDA receptor activation events pathway
REACT_20563
Activation of NMDA receptor upon glutamate binding and postsynaptic events pathway
REACT_20568
CREB phosphorylation through the activation of Ras pathway
REACT_12058
Signalling to ERKs pathway
REACT_12056
NGF signalling via TRKA from the plasma membrane pathway
REACT_13477
Transmission across Chemical Synapses pathway
REACT_12002
ARMS-mediated activation pathway
REACT_12005
Prolonged ERK activation events pathway
REACT_9470
Signaling by FGFR pathway
REACT_15370
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
REACT_111184
Negative regulation of FGFR signaling pathway
REACT_116125
Disease pathway
KEGG
hsa04010
MAPK signaling pathway pathway
hsa04012
ErbB signaling pathway pathway
hsa04062
Chemokine signaling pathway pathway
hsa04150
mTOR signaling pathway pathway
hsa04270
Vascular smooth muscle contraction pathway
hsa04510
Focal adhesion pathway
hsa04650
Natural killer cell mediated cytotoxicity pathway
hsa04720
Long-term potentiation pathway
hsa04722
Neurotrophin signaling pathway pathway
hsa04730
Long-term depression pathway
hsa04810
Regulation of actin cytoskeleton pathway
hsa04910
Insulin signaling pathway pathway
hsa04914
Progesterone-mediated oocyte maturation pathway
hsa05160
Hepatitis C pathway
hsa05200
Pathways in cancer pathway
hsa05210
Colorectal cancer pathway
hsa05211
Renal cell carcinoma pathway
hsa05212
Pancreatic cancer pathway
hsa05213
Endometrial cancer pathway
hsa05214
Glioma pathway
hsa05215
Prostate cancer pathway
hsa05216
Thyroid cancer pathway
hsa05218
Melanoma pathway
hsa05219
Bladder cancer pathway
hsa05220
Chronic myeloid leukemia pathway
hsa05221
Acute myeloid leukemia pathway
hsa05223
Non-small cell lung cancer pathway
INOH
INOH website
IGF1 signaling pathway pathway
INOH website
NGF signaling pathway pathway
INOH website
GPCR signaling pathway
INOH website
IL-7 signaling pathway
INOH website
CD4 T cell receptor signaling pathway
INOH website
JAK STAT pathway and regulation pathway
INOH website
B cell receptor signaling pathway
INOH website
Integrin signaling pathway pathway
INOH website
EPO signaling pathway pathway
INOH website
FGF signaling pathway pathway
INOH website
GPCR Adenosine A2A receptor signaling pathway pathway
INOH website
Insulin receptor signaling pathway
INOH website
VEGF signaling pathway pathway
INOH website
GPCR GroupI metabotropic glutamate receptor signaling pathway pathway
PID BIOCARTA
PID NCI
mapktrkpathway
Trk receptor signaling mediated by the MAPK pathway
cd8tcrdownstreampathway
Downstream signaling in naïve CD8+ T cells
erbb1_downstream_pathway
ErbB1 downstream signaling
fak_pathway
Signaling events mediated by focal adhesion kinase
tcrraspathway
Ras signaling in the CD4+ TCR pathway
vegfr1_2_pathway
Signaling events mediated by VEGFR1 and VEGFR2
pdgfrbpathway
PDGFR-beta signaling pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.550061 Hs.613773
RefSeq NM_004333 XM_005250045
HUGO
OMIM
CCDS CCDS5863
HPRD 01264
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca