Homo sapiens Gene: GAPDHS
Summary
InnateDB Gene IDBG-44465.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GAPDHS
Gene Name glyceraldehyde-3-phosphate dehydrogenase, spermatogenic
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000105679
Encoded Proteins
glyceraldehyde-3-phosphate dehydrogenase, spermatogenic
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein belonging to the glyceraldehyde-3-phosphate dehydrogenase family of enzymes that play an important role in carbohydrate metabolism. Like its somatic cell counterpart, this sperm-specific enzyme functions in a nicotinamide adenine dinucleotide-dependent manner to remove hydrogen and add phosphate to glyceraldehyde 3-phosphate to form 1,3-diphosphoglycerate. During spermiogenesis, this enzyme may play an important role in regulating the switch between different energy-producing pathways, and it is required for sperm motility and male fertility. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:35533412-35545316
Strand Forward strand
Band q13.12
Transcripts
ENST00000222286 ENSP00000222286
ENST00000585510 ENSP00000467255
ENST00000586334 ENSP00000466432
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004365 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GO:0005515 protein binding
GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
GO:0050661 NADP binding
GO:0051287 NAD binding
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006006 glucose metabolic process
GO:0006094 gluconeogenesis
GO:0006096 glycolytic process
GO:0030317 sperm motility
GO:0044281 small molecule metabolic process
GO:0045821 positive regulation of glycolytic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005634 nucleus
GO:0005829 cytosol
GO:0005929 cilium
GO:0031514 motile cilium
GO:0035686 sperm fibrous sheath
GO:0097228 sperm principal piece
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Myoclonic epilepsy of Lafora pathway
Metabolism of carbohydrates pathway
Gluconeogenesis pathway
Glycolysis pathway
Metabolism pathway
Disease pathway
Glucose metabolism pathway
Glycogen storage diseases pathway
KEGG
Glycolysis / Gluconeogenesis pathway
INOH
Glycolysis Gluconeogenesis pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.248017
RefSeq NM_014364
HUGO
OMIM
CCDS CCDS12465
HPRD 13566
IMGT
EMBL
GenPept
RNA Seq Atlas