Homo sapiens Gene: WFDC1
Summary
InnateDB Gene IDBG-44552.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol WFDC1
Gene Name WAP four-disulfide core domain 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000103175
Encoded Proteins
WAP four-disulfide core domain 1
WAP four-disulfide core domain 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the WAP-type four disulfide core domain family. The WAP-type four-disulfide core domain, or WAP signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor in many family members. The encoded protein shares 81% amino acid identity with the rat ps20 protein, which was originally identified as a secreted growth inhibitor. This gene is mapped to chromosome 16q24, an area of frequent loss of heterozygosity in cancers, including prostate, breast and hepatocellular cancers and Wilms' tumor. Owing to its location and a possible growth inhibitory property of its gene product, this gene is suggested to be a tumor suppressor gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:84294646-84329851
Strand Forward strand
Band q24.1
Transcripts
ENST00000219454 ENSP00000219454
ENST00000567056
ENST00000568638 ENSP00000456920
ENST00000613603 ENSP00000481580
ENST00000622779
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0004867 serine-type endopeptidase inhibitor activity
GO:0030414 peptidase inhibitor activity
Biological Process
GO:0001558 regulation of cell growth
GO:0010951 negative regulation of endopeptidase activity
GO:0030308 negative regulation of cell growth
GO:0032355 response to estradiol
GO:0042493 response to drug
GO:0050680 negative regulation of epithelial cell proliferation
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
Orthologs
Species
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
Low
Tentative data, uncurated. RBBH derived.
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001282466 NM_001282467 NM_021197
HUGO
OMIM
CCDS CCDS10946
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas