Homo sapiens Gene: HMGB2
Summary
InnateDB Gene IDBG-44657.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HMGB2
Gene Name high mobility group box 2
Synonyms HMG2;
Species Homo sapiens
Ensembl Gene ENSG00000164104
Encoded Proteins
high mobility group box 2
high mobility group box 2
high mobility group box 2
high mobility group box 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
HMGB2 functions as a universal sentinel for nucleic-acid-mediated innate immune responses.
Entrez Gene
Summary This gene encodes a member of the non-histone chromosomal high mobility group protein family. The proteins of this family are chromatin-associated and ubiquitously distributed in the nucleus of higher eukaryotic cells. In vitro studies have demonstrated that this protein is able to efficiently bend DNA and form DNA circles. These studies suggest a role in facilitating cooperative interactions between cis-acting proteins by promoting DNA flexibility. This protein was also reported to be involved in the final ligation step in DNA end-joining processes of DNA double-strand breaks repair and V(D)J recombination. [provided by RefSeq, Jul 2008]
This gene encodes a member of the non-histone chromosomal high mobility group protein family. The proteins of this family are chromatin-associated and ubiquitously distributed in the nucleus of higher eukaryotic cells. In vitro studies have demonstrated that this protein is able to efficiently bend DNA and form DNA circles. These studies suggest a role in facilitating cooperative interactions between cis-acting proteins by promoting DNA flexibility. This protein was also reported to be involved in the final ligation step in DNA end-joining processes of DNA double-strand breaks repair and V(D)J recombination. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:173331695-173335125
Strand Reverse strand
Band q34.1
Transcripts
ENST00000296503 ENSP00000296503
ENST00000446922 ENSP00000393448
ENST00000438704 ENSP00000404912
ENST00000511316
ENST00000506267 ENSP00000423001
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 33 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 33 [view]
Protein-Protein 30 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003684 damaged DNA binding
GO:0003690 double-stranded DNA binding
GO:0003697 single-stranded DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0008301 DNA binding, bending
GO:0019904 protein domain specific binding
GO:0042056 chemoattractant activity
GO:0044212 transcription regulatory region DNA binding
GO:0044822 poly(A) RNA binding
GO:0050786 RAGE receptor binding
Biological Process
GO:0001938 positive regulation of endothelial cell proliferation
GO:0006265 DNA topological change
GO:0006288 base-excision repair, DNA ligation
GO:0006309 apoptotic DNA fragmentation
GO:0006325 chromatin organization
GO:0006334 nucleosome assembly
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006915 apoptotic process
GO:0006921 cellular component disassembly involved in execution phase of apoptosis
GO:0007283 spermatogenesis
GO:0007289 spermatid nucleus differentiation
GO:0008584 male gonad development
GO:0032075 positive regulation of nuclease activity
GO:0033151 V(D)J recombination
GO:0043388 positive regulation of DNA binding
GO:0045087 innate immune response (InnateDB)
GO:0045648 positive regulation of erythrocyte differentiation
GO:0045654 positive regulation of megakaryocyte differentiation
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048015 phosphatidylinositol-mediated signaling
GO:0048545 response to steroid hormone
GO:0050918 positive chemotaxis
GO:0051103 DNA ligation involved in DNA repair
GO:0060326 cell chemotaxis
GO:0071222 cellular response to lipopolysaccharide
GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
Cellular Component
GO:0000793 condensed chromosome
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0043234 protein complex
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Apoptotic execution phase pathway
Apoptosis induced DNA fragmentation pathway
Activation of DNA fragmentation factor pathway
Apoptosis pathway
KEGG
INOH
PID BIOCARTA
Apoptotic dna-fragmentation and tissue homeostasis [Biocarta view]
Granzyme a mediated apoptosis pathway [Biocarta view]
PID NCI
Cross-References
SwissProt P26583
TrEMBL D6R9A6 Q5U071
UniProt Splice Variant
Entrez Gene 3148
UniGene
RefSeq NM_001130688 NM_001130689 NM_002129
HUGO HGNC:5000
OMIM 163906
CCDS CCDS3816
HPRD
IMGT
EMBL AC097534 AK311864 BC001063 BC100019 BT019782 BT019783 CH471056 M83665 X62534 Z17240
GenPept AAA58659 AAH01063 AAI00020 AAV38585 AAV38586 BAG34805 CAA44395 CAA78938 EAX04758 EAX04759
RNA Seq Atlas 3148