Homo sapiens Gene: COTL1
Summary
InnateDB Gene IDBG-44681.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol COTL1
Gene Name coactosin-like 1 (Dictyostelium)
Synonyms CLP;
Species Homo sapiens
Ensembl Gene ENSG00000103187
Encoded Proteins
coactosin-like 1 (Dictyostelium)
coactosin-like F-actin binding protein 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes one of the numerous actin-binding proteins which regulate the actin cytoskeleton. This protein binds F-actin, and also interacts with 5-lipoxygenase, which is the first committed enzyme in leukotriene biosynthesis. Although this gene has been reported to map to chromosome 17 in the Smith-Magenis syndrome region, the best alignments for this gene are to chromosome 16. The Smith-Magenis syndrome region is the site of two related pseudogenes. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:84565594-84618077
Strand Reverse strand
Band q24.1
Transcripts
ENST00000262428 ENSP00000262428
ENST00000561707
ENST00000567786 ENSP00000480117
ENST00000564057 ENSP00000457033
ENST00000564662
ENST00000567278
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005515 protein binding
GO:0019899 enzyme binding
Biological Process
GO:0008150 biological_process
GO:0050832 defense response to fungus
Cellular Component
GO:0005622 intracellular
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0031965 nuclear membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.289092 Hs.710668
RefSeq NM_021149
HUGO
OMIM
CCDS CCDS10947
HPRD 09482
IMGT
EMBL
GenPept
RNA Seq Atlas