Version 5.4
Homo sapiens Gene: LASP1
Summary
InnateDB Gene IDBG-45070.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LASP1
Gene Name LIM and SH3 protein 1
Synonyms Lasp-1; MLN50
Species Homo sapiens
Ensembl Gene ENSG00000002834
Encoded Proteins
IDBP-45072
LIM and SH3 protein 1
IDBP-376873
LIM and SH3 protein 1
IDBP-376875
LIM and SH3 protein 1
IDBP-376877
LIM and SH3 protein 1
IDBP-376879
LIM and SH3 protein 1
IDBP-759643
IDBP-758866
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of a subfamily of LIM proteins, characterized by a LIM motif and a domain of Src homology region 3, and also a member of the nebulin family of actin-binding proteins. The encoded protein is a cAMP and cGMP dependent signaling protein and binds to the actin cytoskeleton at extensions of the cell membrane. The encoded protein has been linked to metastatic breast cancer, hematopoetic tumors such as B-cell lymphomas, and colorectal cancer. [provided by RefSeq, Oct 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:38869859-38921770
Strand Forward strand
Band q12
Transcripts
ENST00000318008 ENSP00000325240
ENST00000435347 ENSP00000392853
ENST00000433206 ENSP00000401048
ENST00000443937 ENSP00000414803
ENST00000419929 ENSP00000391897
ENST00000581485
ENST00000579123 ENSP00000462564
ENST00000585841 ENSP00000468664
ENST00000584106
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated
Total 27 [view]
Protein-Protein 27 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005070 SH3/SH2 adaptor activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0015075 ion transmembrane transporter activity
GO:0051015 actin filament binding
Biological Process
GO:0006811 ion transport
GO:0009967 positive regulation of signal transduction
GO:0034220 ion transmembrane transport
Cellular Component
GO:0005737 cytoplasm
GO:0005925 focal adhesion
GO:0030864 cortical actin cytoskeleton
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000038366
View Gene Order
ENSBTAG00000030587
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.741156
RefSeq NM_001271608 NM_006148
HUGO
OMIM
CCDS CCDS11331 CCDS62164
HPRD 04229
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca