InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: LIMK2

Summary

InnateDB Gene

IDBG-4518.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LIMK2

Gene Name

LIM domain kinase 2

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000182541

Encoded Proteins

IDBP-4520

LIM domain kinase 2

IDBP-4522

LIM domain kinase 2

IDBP-4524

LIM domain kinase 2

IDBP-294384

LIM domain kinase 2

IDBP-372731

LIM domain kinase 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. The protein encoded by this gene is phosphorylated and activated by ROCK, a downstream effector of Rho, and the encoded protein, in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. It is thought that this pathway contributes to Rho-induced reorganization of the actin cytoskeleton. At least three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 22:31212239-31280080

Strand

Forward strand

Band

q12.2

Transcripts

ENST00000331728	ENSP00000332687
ENST00000333611	ENSP00000330470
ENST00000340552	ENSP00000339916
ENST00000406516	ENSP00000384602
ENST00000425203	ENSP00000388422
ENST00000462625
ENST00000465937
ENST00000482270
ENST00000467301

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	15 [view]
Protein-Protein	13 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008270	zinc ion binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0046982	protein heterodimerization activity

Biological Process

GO:0006468	protein phosphorylation
GO:0007283	spermatogenesis
GO:0016310	phosphorylation
GO:0042325	regulation of phosphorylation

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005801	cis-Golgi network

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000020451

View Gene Order

ENSBTAG00000010662

Not yet available

Pathways

NETPATH

REACTOME

REACT_19277

Sema4D induced cell migration and growth-cone collapse pathway

REACT_19259

Sema4D in semaphorin signaling pathway

REACT_111045

Developmental Biology pathway

REACT_19271

Semaphorin interactions pathway

REACT_228085

EPHB-mediated forward signaling pathway

REACT_18266

Axon guidance pathway

REACT_228170

EPH-Ephrin signaling pathway

KEGG

hsa04810

Regulation of actin cytoskeleton pathway

hsa04360

Axon guidance pathway

hsa04666

Fc gamma R-mediated phagocytosis pathway

INOH

PID NCI

cdc42_pathway

CDC42 signaling events

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.474596 Hs.648392

RefSeq

NM_001031801 NM_005569 NM_016733

HUGO

OMIM

CCDS

CCDS13891 CCDS13892 CCDS33637

HPRD

03585

IMGT

EMBL

GenPept

RNA Seq Atlas