InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: LIMK2

Summary

InnateDB Gene

IDBG-636688.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LIMK2

Gene Name

LIM domain kinase 2

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000010662

Encoded Proteins

IDBP-688638

LIM domain kinase 2

IDBP-688639

LIM domain kinase 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000182541:
There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. The protein encoded by this gene is phosphorylated and activated by ROCK, a downstream effector of Rho, and the encoded protein, in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. It is thought that this pathway contributes to Rho-induced reorganization of the actin cytoskeleton. At least three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:72142468-72196937

Strand

Forward strand

Band

Transcripts

ENSBTAT00000044280	ENSBTAP00000041788
ENSBTAT00000014102	ENSBTAP00000014102

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008270	zinc ion binding
GO:0016301	kinase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0046872	metal ion binding
GO:0046982	protein heterodimerization activity