Version 5.4
Mus musculus Gene: Limk2
Summary
InnateDB Gene IDBG-139221.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Limk2
Gene Name LIM motif-containing protein kinase 2
Synonyms Limk-2
Species Mus musculus
Ensembl Gene ENSMUSG00000020451
Encoded Proteins
IDBP-139223
LIM motif-containing protein kinase 2
IDBP-139229
LIM motif-containing protein kinase 2
IDBP-139231
LIM motif-containing protein kinase 2
IDBP-261130
LIM motif-containing protein kinase 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000182541:
There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. The protein encoded by this gene is phosphorylated and activated by ROCK, a downstream effector of Rho, and the encoded protein, in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. It is thought that this pathway contributes to Rho-induced reorganization of the actin cytoskeleton. At least three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:3344256-3409189
Strand Reverse strand
Band A1
Transcripts
ENSMUST00000101642 ENSMUSP00000099165
ENSMUST00000101640 ENSMUSP00000099163
ENSMUST00000101638 ENSMUSP00000099162
ENSMUST00000110029 ENSMUSP00000105656
ENSMUST00000134576
ENSMUST00000148771
ENSMUST00000142926
ENSMUST00000123689
ENSMUST00000125832
ENSMUST00000132479
ENSMUST00000148091
ENSMUST00000147344
ENSMUST00000145223
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 11 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008270 zinc ion binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0046982 protein heterodimerization activity
Biological Process
GO:0006468 protein phosphorylation
GO:0007283 spermatogenesis
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005801 cis-Golgi network
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000182541
View Gene Order
ENSBTAG00000010662
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04360
Axon guidance pathway
mmu04810
Regulation of actin cytoskeleton pathway
mmu04666
Fc gamma R-mediated phagocytosis pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_19277
Sema4D induced cell migration and growth-cone collapse pathway
REACT_19259
Sema4D in semaphorin signaling pathway
REACT_111045
Developmental Biology pathway
REACT_19271
Semaphorin interactions pathway
REACT_228085
EPHB-mediated forward signaling pathway
REACT_18266
Axon guidance pathway
REACT_228170
EPH-Ephrin signaling pathway
KEGG
hsa04810
Regulation of actin cytoskeleton pathway
hsa04360
Axon guidance pathway
hsa04666
Fc gamma R-mediated phagocytosis pathway
INOH
PID NCI
cdc42_pathway
CDC42 signaling events
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.124176
RefSeq NM_001034030 NM_010718 NM_173053 XM_006514546 XM_006514547 XM_006514548 XM_006514549 XM_006514550 XM_006514551 XM_006514552
OMIM
CCDS CCDS24358 CCDS24359 CCDS24360
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca