Version 5.4
Homo sapiens Gene: SLC15A1
Summary
InnateDB Gene IDBG-45188.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLC15A1
Gene Name solute carrier family 15 (oligopeptide transporter), member 1
Synonyms HPECT1; HPEPT1; PEPT1
Species Homo sapiens
Ensembl Gene ENSG00000088386
Encoded Proteins
IDBP-45190
solute carrier family 15 (oligopeptide transporter), member 1
IDBP-809374
solute carrier family 15 (oligopeptide transporter), member 1
IDBP-809381
solute carrier family 15 (oligopeptide transporter), member 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes an intestinal hydrogen peptide cotransporter that is a member of the solute carrier family 15. The encoded protein is localized to the brush border membrane of the intestinal epithelium and mediates the uptake of di- and tripeptides from the lumen into the enterocytes. This protein plays an important role in the uptake and digestion of dietary proteins. This protein also facilitates the absorption of numerous peptidomimetic drugs. [provided by RefSeq, Apr 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:98683801-98752654
Strand Reverse strand
Band q32.3
Transcripts
ENST00000376503 ENSP00000365686
ENST00000376494
ENST00000613008 ENSP00000482440
ENST00000618992 ENSP00000478051
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005215 transporter activity
GO:0005427 proton-dependent oligopeptide secondary active transmembrane transporter activity
GO:0015198 oligopeptide transporter activity
GO:0015333 peptide:hydrogen symporter activity
Biological Process
GO:0006810 transport
GO:0006811 ion transport
GO:0006857 oligopeptide transport
GO:0007586 digestion
GO:0015031 protein transport
GO:0015992 proton transport
GO:0035672 oligopeptide transmembrane transport
GO:0055085 transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000025557
View Gene Order
ENSBTAG00000004440
Not yet available
Pathways
NETPATH
REACTOME
REACT_19328
Proton/oligonucleotide cotransporters pathway
REACT_19397
Transport of inorganic cations/anions and amino acids/oligopeptides pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_19118
SLC-mediated transmembrane transport pathway
KEGG
hsa04974
Protein digestion and absorption pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL O14496
UniProt Splice Variant
Entrez Gene 6564
UniGene
RefSeq NM_005073
HUGO HGNC:10920
OMIM 600544
CCDS CCDS9489
HPRD
IMGT
EMBL AB001328
GenPept BAA22632
RNA Seq Atlas 6564

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca