Homo sapiens Gene: SLC1A1
Summary
InnateDB Gene IDBG-45967.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLC1A1
Gene Name solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
Synonyms DCBXA; EAAC1; EAAT3; SCZD18;
Species Homo sapiens
Ensembl Gene ENSG00000106688
Encoded Proteins
solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the high-affinity glutamate transporters that play an essential role in transporting glutamate across plasma membranes. In brain, these transporters are crucial in terminating the postsynaptic action of the neurotransmitter glutamate, and in maintaining extracellular glutamate concentrations below neurotoxic levels. This transporter also transports aspartate, and mutations in this gene are thought to cause dicarboxylicamino aciduria, also known as glutamate-aspartate transport defect. [provided by RefSeq, Mar 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:4490444-4587469
Strand Forward strand
Band p24.2
Transcripts
ENST00000262352 ENSP00000262352
ENST00000422398 ENSP00000414620
ENST00000490167
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005313 L-glutamate transmembrane transporter activity
GO:0005515 protein binding
GO:0015501 glutamate:sodium symporter activity
GO:0016595 glutamate binding
GO:0017153 sodium:dicarboxylate symporter activity
Biological Process
GO:0006811 ion transport
GO:0006835 dicarboxylic acid transport
GO:0007268 synaptic transmission
GO:0015813 L-glutamate transport
GO:0051260 protein homooligomerization
GO:0051938 L-glutamate import
GO:0055085 transmembrane transport
GO:0070779 D-aspartate import
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Transmembrane transport of small molecules pathway
Neuronal System pathway
Transport of inorganic cations/anions and amino acids/oligopeptides pathway
Transmission across Chemical Synapses pathway
Neurotransmitter Release Cycle pathway
Glutamate Neurotransmitter Release Cycle pathway
SLC-mediated transmembrane transport pathway
KEGG
Protein digestion and absorption pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.444915 Hs.662818
RefSeq NM_004170
HUGO
OMIM
CCDS CCDS6452
HPRD 00597
IMGT
EMBL
GenPept
RNA Seq Atlas