InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: SLC1A1

Summary

InnateDB Gene

IDBG-631511.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLC1A1

Gene Name

excitatory amino acid transporter 3

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000019125

Encoded Proteins

IDBP-683056

excitatory amino acid transporter 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000106688:
This gene encodes a member of the high-affinity glutamate transporters that play an essential role in transporting glutamate across plasma membranes. In brain, these transporters are crucial in terminating the postsynaptic action of the neurotransmitter glutamate, and in maintaining extracellular glutamate concentrations below neurotoxic levels. This transporter also transports aspartate, and mutations in this gene are thought to cause dicarboxylicamino aciduria, also known as glutamate-aspartate transport defect. [provided by RefSeq, Mar 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 8:40178394-40253322

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000025456

ENSBTAP00000025456

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005313	L-glutamate transmembrane transporter activity
GO:0005515	protein binding
GO:0015501	glutamate:sodium symporter activity
GO:0017153	sodium:dicarboxylate symporter activity

Biological Process

GO:0006835	dicarboxylic acid transport
GO:0015813	L-glutamate transport
GO:0051260	protein homooligomerization
GO:0051938	L-glutamate import
GO:0070779	D-aspartate import