InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CDC23

Summary

InnateDB Gene

IDBG-46810.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CDC23

Gene Name

cell division cycle 23 homolog (S. cerevisiae)

Synonyms

ANAPC8; APC8; CUT23

Species

Homo sapiens

Ensembl Gene

ENSG00000094880

Encoded Proteins

IDBP-240666

cell division cycle 23 homolog (S. cerevisiae)

IDBP-240668

cell division cycle 23 homolog (S. cerevisiae)

IDBP-474273

cell division cycle 23 homolog (S. cerevisiae)

IDBP-475320

cell division cycle 23 homolog (S. cerevisiae)

IDBP-475056

cell division cycle 23 homolog (S. cerevisiae)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene shares strong similarity with Saccharomyces cerevisiae Cdc23, a protein essential for cell cycle progression through the G2/M transition. This protein is a component of anaphase-promoting complex (APC), which is composed of eight protein subunits and highly conserved in eukaryotic cells. APC catalyzes the formation of cyclin B-ubiquitin conjugate that is responsible for the ubiquitin-mediated proteolysis of B-type cyclins. This protein and 3 other members of the APC complex contain the TPR (tetratricopeptide repeat), a protein domain important for protein-protein interaction. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:138187648-138213343

Strand

Reverse strand

Band

q31.2

Transcripts

ENST00000394886	ENSP00000378350
ENST00000394884	ENSP00000378348
ENST00000464806
ENST00000475021
ENST00000471692
ENST00000482948
ENST00000483961	ENSP00000422505
ENST00000511383	ENSP00000422902
ENST00000505120	ENSP00000423704

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 91 experimentally validated interaction(s) in this database.

Experimentally validated
Total	91 [view]
Protein-Protein	87 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding

Biological Process

GO:0000080	mitotic G1 phase
GO:0000278	mitotic cell cycle
GO:0006511	ubiquitin-dependent protein catabolic process
GO:0007049	cell cycle
GO:0007067	mitotic nuclear division
GO:0007080	mitotic metaphase plate congression
GO:0007091	metaphase/anaphase transition of mitotic cell cycle
GO:0007094	mitotic spindle assembly checkpoint
GO:0007096	regulation of exit from mitosis
GO:0030071	regulation of mitotic metaphase/anaphase transition
GO:0031145	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0051436	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051437	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051439	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0070979	protein K11-linked ubiquitination