InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: PTPRR

Summary

InnateDB Gene

IDBG-47763.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PTPRR

Gene Name

protein tyrosine phosphatase, receptor type, R

Synonyms

EC-PTP; PCPTP1; PTP-SL; PTPBR7; PTPRQ

Species

Homo sapiens

Ensembl Gene

ENSG00000153233

Encoded Proteins

IDBP-47765

protein tyrosine phosphatase, receptor type, R

IDBP-47767

protein tyrosine phosphatase, receptor type, R

IDBP-47769

protein tyrosine phosphatase, receptor type, R

IDBP-380093

protein tyrosine phosphatase, receptor type, R

IDBP-588334

protein tyrosine phosphatase, receptor type, R

IDBP-597159

protein tyrosine phosphatase, receptor type, R

IDBP-586171

protein tyrosine phosphatase, receptor type, R

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single intracellular catalytic domain, and thus represents a receptor-type PTP. Silencing of this gene has been associated with colorectal cancer. Multiple transcript variants encoding different isoforms have been found for this gene. This gene shares a symbol (PTPRQ) with another gene, protein tyrosine phosphatase, receptor type, Q (GeneID 374462), which is also located on chromosome 12. [provided by RefSeq, May 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 12:70638073-70920843

Strand

Reverse strand

Band

q15

Transcripts

ENST00000283228	ENSP00000283228
ENST00000378778	ENSP00000368054
ENST00000342084	ENSP00000339605
ENST00000440835	ENSP00000391750
ENST00000537619
ENST00000551219	ENSP00000448049
ENST00000547752
ENST00000549308	ENSP00000446943
ENST00000549107
ENST00000548220
ENST00000550661	ENSP00000449616

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	13 [view]
Protein-Protein	12 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004725	protein tyrosine phosphatase activity
GO:0005001	transmembrane receptor protein tyrosine phosphatase activity
GO:0005515	protein binding
GO:0016791	phosphatase activity
GO:0019901	protein kinase binding

Biological Process

GO:0001701	in utero embryonic development
GO:0006470	protein dephosphorylation
GO:0016311	dephosphorylation
GO:0035335	peptidyl-tyrosine dephosphorylation

Cellular Component

GO:0005615	extracellular space
GO:0005886	plasma membrane
GO:0016021	integral component of membrane
GO:0048471	perinuclear region of cytoplasm

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000020151

View Gene Order

ENSBTAG00000015311

Not yet available

Pathways

NETPATH

NetPath_4

EGFR1 pathway

NetPath_25

FSH pathway

REACTOME

KEGG

hsa04010

MAPK signaling pathway pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.506076

RefSeq

NM_001207015 NM_001207016 NM_002849 NM_130846

HUGO

OMIM

CCDS

CCDS44945 CCDS55847 CCDS55848 CCDS8998

HPRD

04169

IMGT

EMBL

GenPept

RNA Seq Atlas