Homo sapiens Gene: PTPRR
Summary
InnateDB Gene IDBG-47763.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PTPRR
Gene Name protein tyrosine phosphatase, receptor type, R
Synonyms EC-PTP; PCPTP1; PTP-SL; PTPBR7; PTPRQ;
Species Homo sapiens
Ensembl Gene ENSG00000153233
Encoded Proteins
protein tyrosine phosphatase, receptor type, R
protein tyrosine phosphatase, receptor type, R
protein tyrosine phosphatase, receptor type, R
protein tyrosine phosphatase, receptor type, R
protein tyrosine phosphatase, receptor type, R
protein tyrosine phosphatase, receptor type, R
protein tyrosine phosphatase, receptor type, R
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single intracellular catalytic domain, and thus represents a receptor-type PTP. Silencing of this gene has been associated with colorectal cancer. Multiple transcript variants encoding different isoforms have been found for this gene. This gene shares a symbol (PTPRQ) with another gene, protein tyrosine phosphatase, receptor type, Q (GeneID 374462), which is also located on chromosome 12. [provided by RefSeq, May 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:70638073-70920843
Strand Reverse strand
Band q15
Transcripts
ENST00000283228 ENSP00000283228
ENST00000378778 ENSP00000368054
ENST00000342084 ENSP00000339605
ENST00000440835 ENSP00000391750
ENST00000537619
ENST00000551219 ENSP00000448049
ENST00000547752
ENST00000549308 ENSP00000446943
ENST00000549107
ENST00000548220
ENST00000550661 ENSP00000449616
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 13 [view]
Protein-Protein 12 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004725 protein tyrosine phosphatase activity
GO:0005001 transmembrane receptor protein tyrosine phosphatase activity
GO:0005515 protein binding
GO:0016791 phosphatase activity
GO:0019901 protein kinase binding
Biological Process
GO:0001701 in utero embryonic development
GO:0006470 protein dephosphorylation
GO:0016311 dephosphorylation
GO:0035335 peptidyl-tyrosine dephosphorylation
Cellular Component
GO:0005615 extracellular space
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
EGFR1 pathway
FSH pathway
REACTOME
KEGG
MAPK signaling pathway pathway
INOH
PID BIOCARTA
Erk1/erk2 mapk signaling pathway [Biocarta view]
PID NCI
Cross-References
SwissProt Q15256
TrEMBL F8VVE9 Q68CP6
UniProt Splice Variant
Entrez Gene 5801
UniGene Hs.506076
RefSeq NM_001207016 NM_002849 NM_130846 NM_001207015
HUGO HGNC:9680
OMIM 602853
CCDS CCDS55847 CCDS8998 CCDS44945 CCDS55848
HPRD 04169
IMGT
EMBL AC083809 AC084877 AC090676 AC140066 AF263016 AF263017 AF263018 AF263019 AF263020 AF263021 AF263022 AF263023 AF263024 AF263025 AF263026 AF263027 AF263028 AF263029 AK295951 AK312376 CR749836 D64053 U42361 U77916 U77917 X82635 Z79693
GenPept AAB54006 AAB54007 AAD09447 AAG47642 BAA10930 BAG35294 BAH12227 CAA57957 CAB01957 CAH18692
RNA Seq Atlas 5801