Version 5.4
Bos taurus Gene: PTPRR
Summary
InnateDB Gene IDBG-633690.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PTPRR
Gene Name receptor-type tyrosine-protein phosphatase R isoform 2 precursor
Synonyms PCPTP1
Species Bos taurus
Ensembl Gene ENSBTAG00000015311
Encoded Proteins
IDBP-685437
protein tyrosine phosphatase, receptor type, R isoform 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000153233:
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single intracellular catalytic domain, and thus represents a receptor-type PTP. Silencing of this gene has been associated with colorectal cancer. Multiple transcript variants encoding different isoforms have been found for this gene. This gene shares a symbol (PTPRQ) with another gene, protein tyrosine phosphatase, receptor type, Q (GeneID 374462), which is also located on chromosome 12. [provided by RefSeq, May 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:42837597-43112731
Strand Forward strand
Band
Transcripts
ENSBTAT00000020359 ENSBTAP00000020359
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004721 phosphoprotein phosphatase activity
GO:0004725 protein tyrosine phosphatase activity
GO:0005515 protein binding
GO:0016787 hydrolase activity
GO:0016791 phosphatase activity
GO:0019901 protein kinase binding
Biological Process
GO:0001701 in utero embryonic development
GO:0006470 protein dephosphorylation
GO:0016311 dephosphorylation
Cellular Component
GO:0005615 extracellular space
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000153233
View Gene Order
ENSMUSG00000020151
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_4
EGFR1 pathway
NetPath_25
FSH pathway
REACTOME
KEGG
hsa04010
MAPK signaling pathway pathway
mmu04010
MAPK signaling pathway pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL A5PKF8
UniProt Splice Variant
Entrez Gene 536337
UniGene Bt.1069 Bt.109341
RefSeq NM_001113261
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC142472 DAAA02013191 DAAA02013192 DAAA02013193 DAAA02013194 DAAA02013195 DAAA02013196 DAAA02013197 DAAA02013198
GenPept AAI42473
RNA Seq Atlas 536337

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca