Version 5.4
Homo sapiens Gene: ABP1
Summary
InnateDB Gene IDBG-48285.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ABP1
Gene Name amiloride binding protein 1 (amine oxidase (copper-containing))
Synonyms ABP; ABP1; DAO; DAO1; KAO
Species Homo sapiens
Ensembl Gene ENSG00000002726
Encoded Proteins
IDBP-48287
amiloride binding protein 1 (amine oxidase (copper-containing))
IDBP-387328
amiloride binding protein 1 (amine oxidase (copper-containing))
IDBP-473635
amiloride binding protein 1 (amine oxidase (copper-containing))
IDBP-478173
amiloride binding protein 1 (amine oxidase (copper-containing))
IDBP-485224
amiloride binding protein 1 (amine oxidase (copper-containing))
IDBP-482373
amiloride binding protein 1 (amine oxidase (copper-containing))
IDBP-813450
amine oxidase, copper containing 1
IDBP-813451
amine oxidase, copper containing 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a metal-binding membrane glycoprotein that oxidatively deaminates putrescine, histamine, and related compounds. The encoded protein is inhibited by amiloride, a diuretic that acts by closing epithelial sodium ion channels. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:150824627-150861504
Strand Forward strand
Band q36.1
Transcripts
ENST00000360937 ENSP00000354193
ENST00000416793 ENSP00000411613
ENST00000493429 ENSP00000418614
ENST00000467291 ENSP00000418328
ENST00000460213 ENSP00000418557
ENST00000483043 ENSP00000417392
ENST00000480582
ENST00000619575 ENSP00000481717
ENST00000622116 ENSP00000481520
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004872 receptor activity
GO:0005261 cation channel activity
GO:0005272 sodium channel activity
GO:0005507 copper ion binding
GO:0005509 calcium ion binding
GO:0008131 primary amine oxidase activity
GO:0008144 drug binding
GO:0008201 heparin binding
GO:0008270 zinc ion binding
GO:0032403 protein complex binding
GO:0042803 protein homodimerization activity
GO:0048038 quinone binding
GO:0052597 diamine oxidase activity
GO:0052598 histamine oxidase activity
GO:0052599 methylputrescine oxidase activity
GO:0052600 propane-1,3-diamine oxidase activity
Biological Process
GO:0009308 amine metabolic process
GO:0035725 sodium ion transmembrane transport
GO:0035874 cellular response to copper ion starvation
GO:0042493 response to drug
GO:0046677 response to antibiotic
GO:0055114 oxidation-reduction process
GO:0071280 cellular response to copper ion
GO:0071420 cellular response to histamine
GO:0071504 cellular response to heparin
GO:0097185 cellular response to azide
Cellular Component
GO:0005615 extracellular space
GO:0005777 peroxisome
GO:0005886 plasma membrane
GO:0005923 tight junction
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000029811
View Gene Order
ENSBTAG00000005419
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa00340
Histidine metabolism pathway
hsa00330
Arginine and proline metabolism pathway
hsa00380
Tryptophan metabolism pathway
INOH
INOH website
Tryptophan degradation pathway
INOH website
Phenylalanine degradation pathway
INOH website
Arginine Proline metabolism pathway
INOH website
Tyrosine metabolism pathway
INOH website
Glycine Serine metabolism pathway
INOH website
Histidine degradation pathway
PID NCI
Cross-References
SwissProt
TrEMBL C9J0G8 C9J2J4
UniProt Splice Variant
Entrez Gene 26
UniGene Hs.736883
RefSeq NM_001091 NM_001272072 XM_005249967 XM_006715918
HUGO HGNC:80
OMIM 104610
CCDS CCDS43679 CCDS64797
HPRD 00088
IMGT
EMBL AC006343 AC006479
GenPept
RNA Seq Atlas 26

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca