Version 5.4
Homo sapiens Gene: PTPRQ
Summary
InnateDB Gene IDBG-49597.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PTPRQ
Gene Name protein tyrosine phosphatase, receptor type, Q
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000139304
Encoded Proteins
IDBP-591072
protein tyrosine phosphatase, receptor type, Q
IDBP-593312
protein tyrosine phosphatase, receptor type, Q
IDBP-588023
protein tyrosine phosphatase, receptor type, Q
IDBP-585732
protein tyrosine phosphatase, receptor type, Q
IDBP-811021
protein tyrosine phosphatase, receptor type, Q
IDBP-811025
protein tyrosine phosphatase, receptor type, Q
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This locus encodes a member of the type III receptor-like protein-tyrosine phosphatase family. The encoded protein catalyzes the dephosphorylation of phosphotyrosine and phosphatidylinositol and plays roles in cellular proliferation and differentiation. Mutations at this locus are associated with hearing loss. [provided by RefSeq, Jan 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:80402178-80680234
Strand Forward strand
Band q21.31
Transcripts
ENST00000551042 ENSP00000447522
ENST00000547376 ENSP00000448844
ENST00000551573 ENSP00000449133
ENST00000547485
ENST00000551624
ENST00000547881 ENSP00000449526
ENST00000549355
ENST00000623635
ENST00000614701 ENSP00000482885
ENST00000616559 ENSP00000483259
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004725 protein tyrosine phosphatase activity
GO:0005515 protein binding
GO:0016791 phosphatase activity
Biological Process
GO:0002244 hematopoietic progenitor cell differentiation
GO:0006470 protein dephosphorylation
GO:0016311 dephosphorylation
GO:0042472 inner ear morphogenesis
GO:0050885 neuromuscular process controlling balance
GO:0050910 detection of mechanical stimulus involved in sensory perception of sound
GO:0060116 vestibular receptor cell morphogenesis
Cellular Component
GO:0032421 stereocilium bundle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000035916
View Gene Order
ENSBTAG00000026977
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 374462
UniGene
RefSeq NM_001145026
HUGO HGNC:9679
OMIM 603317
CCDS CCDS73501
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas 374462

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca