Homo sapiens Gene: SARS2
Summary
InnateDB Gene IDBG-49809.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SARS2
Gene Name seryl-tRNA synthetase 2, mitochondrial
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000104835
Encoded Proteins
F-box protein 17
F-box protein 17
F-box protein 17
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes the mitochondrial seryl-tRNA synthethase precursor, a member of the class II tRNA synthetase family. The mature enzyme catalyzes the ligation of Serine to tRNA(Ser) and participates in the biosynthesis of selenocysteinyl-tRNA(sec) in mitochondria. The enzyme contains an N-terminal tRNA binding domain and a core catalytic domain. It functions in a homodimeric form, which is stabilized by tRNA binding. This gene is regulated by a bidirectional promoter that also controls the expression of mitochondrial ribosomal protein S12. Both genes are within the critical interval for the autosomal dominant deafness locus DFNA4 and might be linked to this disease. Multiple transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Mar 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:38915266-38930896
Strand Reverse strand
Band q13.2
Transcripts
ENST00000221431 ENSP00000221431
ENST00000430193 ENSP00000406754
ENST00000455102 ENSP00000414954
ENST00000598343 ENSP00000472576
ENST00000594171 ENSP00000472339
ENST00000597490
ENST00000598563
ENST00000598831 ENSP00000468865
ENST00000602034
ENST00000600042 ENSP00000472847
ENST00000598598
ENST00000593754 ENSP00000471767
ENST00000594259
ENST00000600448
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
Experimentally validated
Total 22 [view]
Protein-Protein 21 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0004812 aminoacyl-tRNA ligase activity
GO:0004828 serine-tRNA ligase activity
GO:0005524 ATP binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006418 tRNA aminoacylation for protein translation
GO:0006434 seryl-tRNA aminoacylation
GO:0010467 gene expression
GO:0097056 selenocysteinyl-tRNA(Sec) biosynthetic process
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Mitochondrial tRNA aminoacylation pathway
tRNA Aminoacylation pathway
Gene Expression pathway
KEGG
Aminoacyl-tRNA biosynthesis pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL M0R2H5
UniProt Splice Variant
Entrez Gene 54938
UniGene Hs.709416
RefSeq NM_001145901 NM_017827
HUGO HGNC:17697
OMIM 612804
CCDS CCDS33017 CCDS54265
HPRD 15295
IMGT
EMBL AC011455
GenPept
RNA Seq Atlas 54938