Version 5.4
Homo sapiens Gene: KITLG
Summary
InnateDB Gene IDBG-50398.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KITLG
Gene Name KIT ligand
Synonyms FPH2; Kitl; KL-1; MGF; SCF; SF; SHEP7;
Species Homo sapiens
Ensembl Gene ENSG00000049130
Encoded Proteins
IDBP-50400
KIT ligand
IDBP-50402
KIT ligand
IDBP-810663
KIT ligand
IDBP-810665
KIT ligand
IDBP-810668
KIT ligand
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 21262348
KITLG is a PI3K-activating ligand that increases the secretion of IL6 and TNFA in LPS-stimulated mast cells, as well as the attenuating the production of IL1B. (Demonstrated in murine model)
InnateDB Annotation from Orthologs
Summary
PMID 21262348
[Mus musculus] Kitl is a PI3K-activating ligand that increases the secretion of Il6 and Tnfa in LPS-stimulated mast cells, as well as the attenuating the production of Il1b.
Entrez Gene
Summary This gene encodes the ligand of the tyrosine-kinase receptor encoded by the KIT locus. This ligand is a pleiotropic factor that acts in utero in germ cell and neural cell development, and hematopoiesis, all believed to reflect a role in cell migration. In adults, it functions pleiotropically, while mostly noted for its continued requirement in hematopoiesis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:88492793-88580851
Strand Reverse strand
Band q21.32
Transcripts
ENST00000228280 ENSP00000228280
ENST00000347404 ENSP00000054216
ENST00000357116 ENSP00000474021
ENST00000378535
ENST00000552044 ENSP00000475042
ENST00000613305 ENSP00000479271
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 11 [view]
Protein-Protein 8 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005125 cytokine activity
GO:0005173 stem cell factor receptor binding
GO:0005515 protein binding
GO:0008083 growth factor activity
Biological Process
GO:0001755 neural crest cell migration
GO:0002763 positive regulation of myeloid leukocyte differentiation
GO:0007155 cell adhesion
GO:0007165 signal transduction
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0008283 cell proliferation
GO:0008284 positive regulation of cell proliferation
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0008584 male gonad development
GO:0033026 negative regulation of mast cell apoptotic process
GO:0035162 embryonic hemopoiesis
GO:0035234 ectopic germ cell programmed cell death
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0043066 negative regulation of apoptotic process
GO:0043406 positive regulation of MAP kinase activity
GO:0045087 innate immune response (InnateDB)
GO:0045636 positive regulation of melanocyte differentiation
GO:0045740 positive regulation of DNA replication
GO:0046579 positive regulation of Ras protein signal transduction
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0048015 phosphatidylinositol-mediated signaling
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0070668 positive regulation of mast cell proliferation
GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
ENSMUSG00000019966
View Gene Order
Ortholuge
SSD Ortholog
Ortholog supports species divergence
ENSBTAG00000017549
Not yet available
Ortholuge
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
NetPath_6
KitReceptor pathway
REACTOME
KEGG
hsa04060
Cytokine-cytokine receptor interaction pathway
hsa04640
Hematopoietic cell lineage pathway
hsa04916
Melanogenesis pathway
hsa05200
Pathways in cancer pathway
INOH
INOH website
GPCR signaling pathway
INOH website
JAK STAT pathway and regulation pathway
PID BIOCARTA
100110
Cdk regulation of dna replication [Biocarta view]
100108
Melanocyte development and pigmentation pathway [Biocarta view]
100233
Regulation of bad phosphorylation [Biocarta view]
PID NCI
cmyb_pathway
C-MYB transcription factor network
kitpathway
Signaling events mediated by Stem cell factor receptor (c-Kit)
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_000899 NM_003994
HUGO
OMIM
CCDS CCDS31867 CCDS31868
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca