|Homo sapiens Gene: KITLG|
|Last Modified||2014-10-13 [Report errors or provide feedback]|
|Gene Name||KIT ligand|
|Synonyms||FPH2; Kitl; KL-1; MGF; SCF; SF; SHEP7;|
|Useful resources||Stemformatics EHFPI ImmGen|
KITLG is a PI3K-activating ligand that increases the secretion of IL6 and TNFA in LPS-stimulated mast cells, as well as the attenuating the production of IL1B. (Demonstrated in murine model)
|InnateDB Annotation from Orthologs|
[Mus musculus] Kitl is a PI3K-activating ligand that increases the secretion of Il6 and Tnfa in LPS-stimulated mast cells, as well as the attenuating the production of Il1b.
This gene encodes the ligand of the tyrosine-kinase receptor encoded by the KIT locus. This ligand is a pleiotropic factor that acts in utero in germ cell and neural cell development, and hematopoiesis, all believed to reflect a role in cell migration. In adults, it functions pleiotropically, while mostly noted for its continued requirement in hematopoiesis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
|Genomic Location||Chromosome 12:88492793-88580851|
|Number of Interactions||
This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Cytokine-cytokine receptor interaction pathway
Hematopoietic cell lineage pathway
Pathways in cancer pathway
GPCR signaling pathway
JAK STAT pathway and regulation pathway
C-MYB transcription factor network
Signaling events mediated by Stem cell factor receptor (c-Kit)
|UniProt Splice Variant|
|RNA Seq Atlas|