Homo sapiens Gene: PIGF
Summary
InnateDB Gene IDBG-50448.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PIGF
Gene Name phosphatidylinositol glycan anchor biosynthesis, class F
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000151665
Encoded Proteins
phosphatidylinositol glycan anchor biosynthesis, class F
phosphatidylinositol glycan anchor biosynthesis, class F
phosphatidylinositol glycan anchor biosynthesis, class F
phosphatidylinositol glycan anchor biosynthesis, class F
phosphatidylinositol glycan anchor biosynthesis, class F
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein involved in glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor, a glycolipid containing three mannose molecules in its core backbone, is found on many blood cells where it serves to anchor proteins to the cell surface. The encoded protein and another GPI synthesis protein, PIGO, function in the transfer of ethanolaminephosphate to the third mannose in GPI. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:46580937-46617119
Strand Reverse strand
Band p21
Transcripts
ENST00000306465 ENSP00000302663
ENST00000281382 ENSP00000281382
ENST00000420164 ENSP00000410361
ENST00000412717 ENSP00000413202
ENST00000482786
ENST00000495933
ENST00000474980 ENSP00000429355
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 0
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004307 ethanolaminephosphotransferase activity
Biological Process
GO:0006501 C-terminal protein lipidation
GO:0006506 GPI anchor biosynthetic process
GO:0016254 preassembly of GPI anchor in ER membrane
GO:0043687 post-translational protein modification
GO:0044267 cellular protein metabolic process
Cellular Component
GO:0005789 endoplasmic reticulum membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Post-translational modification: synthesis of GPI-anchored proteins pathway
Post-translational protein modification pathway
Synthesis of glycosylphosphatidylinositol (GPI) pathway
Metabolism of proteins pathway
KEGG
Glycosylphosphatidylinositol(GPI)-anchor biosynthesis pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL H7C392
UniProt Splice Variant
Entrez Gene 5281
UniGene Hs.468415
RefSeq NM_173074 NM_002643
HUGO HGNC:8962
OMIM 600153
CCDS CCDS1828 CCDS1827
HPRD 02539
IMGT
EMBL AC018682
GenPept
RNA Seq Atlas 5281