Homo sapiens Gene: FADS2
Summary
InnateDB Gene IDBG-50591.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FADS2
Gene Name fatty acid desaturase 2
Synonyms D6D; DES6; FADSD6; LLCDL2; SLL0262; TU13;
Species Homo sapiens
Ensembl Gene ENSG00000134824
Encoded Proteins
fatty acid desaturase 2
fatty acid desaturase 2
fatty acid desaturase 2
fatty acid desaturase 2
fatty acid desaturase 2
fatty acid desaturase 2
fatty acid desaturase 2
fatty acid desaturase 2
fatty acid desaturase 2
fatty acid desaturase 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the fatty acid desaturase (FADS) gene family. Desaturase enzymes regulate unsaturation of fatty acids through the introduction of double bonds between defined carbons of the fatty acyl chain. FADS family members are considered fusion products composed of an N-terminal cytochrome b5-like domain and a C-terminal multiple membrane-spanning desaturase portion, both of which are characterized by conserved histidine motifs. This gene is clustered with family members FADS1 and FADS2 at 11q12-q13.1; this cluster is thought to have arisen evolutionarily from gene duplication based on its similar exon/intron organization. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is a member of the fatty acid desaturase (FADS) gene family. Desaturase enzymes regulate unsaturation of fatty acids through the introduction of double bonds between defined carbons of the fatty acyl chain. FADS family members are considered fusion products composed of an N-terminal cytochrome b5-like domain and a C-terminal multiple membrane-spanning desaturase portion, both of which are characterized by conserved histidine motifs. This gene is clustered with family members at 11q12-q13.1; this cluster is thought to have arisen evolutionarily from gene duplication based on its similar exon/intron organization. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:61792980-61867354
Strand Forward strand
Band q12.2
Transcripts
ENST00000257261 ENSP00000257261
ENST00000278840 ENSP00000278840
ENST00000355484 ENSP00000437965
ENST00000522639 ENSP00000428522
ENST00000522056 ENSP00000429500
ENST00000517839 ENSP00000429693
ENST00000518606 ENSP00000430054
ENST00000517312 ENSP00000430225
ENST00000521849 ENSP00000431091
ENST00000520145
ENST00000523235
ENST00000521571 ENSP00000443867
ENST00000522359
ENST00000543584
ENST00000574708 ENSP00000458917
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004768 stearoyl-CoA 9-desaturase activity
GO:0005506 iron ion binding
GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water
GO:0020037 heme binding
Biological Process
GO:0006629 lipid metabolic process
GO:0006633 fatty acid biosynthetic process
GO:0006636 unsaturated fatty acid biosynthetic process
GO:0033559 unsaturated fatty acid metabolic process
GO:0036109 alpha-linolenic acid metabolic process
GO:0043651 linoleic acid metabolic process
GO:0044281 small molecule metabolic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005789 endoplasmic reticulum membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Metabolism of lipids and lipoproteins pathway
alpha-linolenic acid (ALA) metabolism pathway
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism pathway
Linoleic acid (LA) metabolism pathway
Metabolism pathway
KEGG
alpha-Linolenic acid metabolism pathway
Biosynthesis of unsaturated fatty acids pathway
PPAR signaling pathway pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt O95864
TrEMBL B3KVS0 E5RGD8 E5RGZ5 E5RHL3 F5GZ92 F5GZU2 F5H622
UniProt Splice Variant
Entrez Gene 9415
UniGene Hs.502745 Hs.709486 Hs.734202
RefSeq NM_001281501 NM_001281502 NM_004265
HUGO HGNC:3575
OMIM 606149
CCDS CCDS60807 CCDS60808 CCDS8012
HPRD
IMGT
EMBL AF084559 AF108658 AF126799 AK027513 AK074939 AK123240 AK290291 AK299762 AL050118 AP002380 BC009011 BX640945 CH471076
GenPept AAD20018 AAG23121 AAG43192 AAH09011 BAB55167 BAC11305 BAF82980 BAG53882 BAH13120 CAB43280 CAE45971 EAW73975
RNA Seq Atlas 9415