Homo sapiens Gene: MNX1
Summary
InnateDB Gene IDBG-50743.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MNX1
Gene Name motor neuron and pancreas homeobox 1
Synonyms HB9; HLXB9; HOXHB9; SCRA1;
Species Homo sapiens
Ensembl Gene ENSG00000130675
Encoded Proteins
motor neuron and pancreas homeobox 1
motor neuron and pancreas homeobox 1
motor neuron and pancreas homeobox 1
motor neuron and pancreas homeobox 1
motor neuron and pancreas homeobox 1
motor neuron and pancreas homeobox 1
motor neuron and pancreas homeobox 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a nuclear protein, which contains a homeobox domain and is a transcription factor. Mutations in this gene result in Currarino syndrome, an autosomic dominant congenital malformation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:156994051-157010651
Strand Reverse strand
Band q36.3
Transcripts
ENST00000252971 ENSP00000252971
ENST00000428439 ENSP00000401158
ENST00000425745 ENSP00000416458
ENST00000479817 ENSP00000474286
ENST00000469500 ENSP00000475129
ENST00000474448 ENSP00000473965
ENST00000543409 ENSP00000438552
ENST00000605400
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0001764 neuron migration
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006959 humoral immune response
GO:0008045 motor neuron axon guidance
GO:0009653 anatomical structure morphogenesis
GO:0009791 post-embryonic development
GO:0021520 spinal cord motor neuron cell fate specification
GO:0021675 nerve development
GO:0021904 dorsal/ventral neural tube patterning
GO:0021953 central nervous system neuron differentiation
GO:0030182 neuron differentiation
GO:0031016 pancreas development
GO:0031018 endocrine pancreas development
GO:0048667 cell morphogenesis involved in neuron differentiation
GO:0048812 neuron projection morphogenesis
GO:0060539 diaphragm development
GO:0060541 respiratory system development
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
KEGG
Maturity onset diabetes of the young pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.37035
RefSeq NM_001165255 NM_005515
HUGO
OMIM
CCDS CCDS34788 CCDS55187
HPRD 00874
IMGT
EMBL
GenPept
RNA Seq Atlas