Version 5.4
Homo sapiens Gene: MNX1
Summary
InnateDB Gene IDBG-50743.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MNX1
Gene Name motor neuron and pancreas homeobox 1
Synonyms HB9; HLXB9; HOXHB9; SCRA1
Species Homo sapiens
Ensembl Gene ENSG00000130675
Encoded Proteins
IDBP-50745
motor neuron and pancreas homeobox 1
IDBP-387579
motor neuron and pancreas homeobox 1
IDBP-387580
motor neuron and pancreas homeobox 1
IDBP-812169
motor neuron and pancreas homeobox 1
IDBP-812167
motor neuron and pancreas homeobox 1
IDBP-812175
motor neuron and pancreas homeobox 1
IDBP-590677
motor neuron and pancreas homeobox 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a nuclear protein, which contains a homeobox domain and is a transcription factor. Mutations in this gene result in Currarino syndrome, an autosomic dominant congenital malformation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:156994051-157010651
Strand Reverse strand
Band q36.3
Transcripts
ENST00000252971 ENSP00000252971
ENST00000428439 ENSP00000401158
ENST00000425745 ENSP00000416458
ENST00000479817 ENSP00000474286
ENST00000469500 ENSP00000475129
ENST00000474448 ENSP00000473965
ENST00000543409 ENSP00000438552
ENST00000605400
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0001764 neuron migration
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006959 humoral immune response
GO:0008045 motor neuron axon guidance
GO:0009653 anatomical structure morphogenesis
GO:0009791 post-embryonic development
GO:0021520 spinal cord motor neuron cell fate specification
GO:0021675 nerve development
GO:0021904 dorsal/ventral neural tube patterning
GO:0021953 central nervous system neuron differentiation
GO:0030182 neuron differentiation
GO:0031016 pancreas development
GO:0031018 endocrine pancreas development
GO:0048667 cell morphogenesis involved in neuron differentiation
GO:0048812 neuron projection morphogenesis
GO:0060539 diaphragm development
GO:0060541 respiratory system development
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000001566
View Gene Order
ENSBTAG00000030876
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa04950
Maturity onset diabetes of the young pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL S4R364
UniProt Splice Variant
Entrez Gene 3110
UniGene
RefSeq NM_001165255 NM_005515
HUGO HGNC:4979
OMIM 142994
CCDS CCDS34788 CCDS55187
HPRD
IMGT
EMBL AC006357
GenPept
RNA Seq Atlas 3110

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca