Version 5.4
Homo sapiens Gene: USP44
Summary
InnateDB Gene IDBG-51735.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol USP44
Gene Name ubiquitin specific peptidase 44
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000136014
Encoded Proteins
IDBP-51737
ubiquitin specific peptidase 44
IDBP-244330
ubiquitin specific peptidase 44
IDBP-602155
ubiquitin specific peptidase 44
IDBP-583401
ubiquitin specific peptidase 44
IDBP-603008
ubiquitin specific peptidase 44
IDBP-584560
ubiquitin specific peptidase 44
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Modification of cellular proteins by ubiquitin is an essential regulatory mechanism controlled by the coordinated action of multiple ubiquitin-conjugating and deubiquitinating enzymes. USP44 belongs to a large family of cysteine proteases that function as deubiquitinating enzymes (Quesada et al., 2004 [PubMed 14715245]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:95516560-95551490
Strand Reverse strand
Band q22
Transcripts
ENST00000258499 ENSP00000258499
ENST00000393091 ENSP00000376806
ENST00000552440 ENSP00000448670
ENST00000537435 ENSP00000442629
ENST00000552237
ENST00000551837 ENSP00000448601
ENST00000549639 ENSP00000449635
ENST00000547951
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
Experimentally validated
Total 12 [view]
Protein-Protein 12 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004221 ubiquitin thiolesterase activity
GO:0004843 ubiquitin-specific protease activity
GO:0005515 protein binding
GO:0008234 cysteine-type peptidase activity
GO:0008270 zinc ion binding
GO:0036459 ubiquitinyl hydrolase activity
Biological Process
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0007067 mitotic nuclear division
GO:0016579 protein deubiquitination
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0051322 anaphase
GO:0060564 negative regulation of mitotic anaphase-promoting complex activity
GO:0090231 regulation of spindle checkpoint
GO:0090266 regulation of mitotic cell cycle spindle assembly checkpoint
Cellular Component
GO:0005634 nucleus
Orthologs
No orthologs found for this gene
Cross-References
SwissProt Q9H0E7
TrEMBL A0A024RBD7 F8VRW0 F8VVD6
UniProt Splice Variant
Entrez Gene 84101
UniGene Hs.646421 Hs.710121 Hs.736443
RefSeq NM_001278393 NM_001042403 NM_032147 XM_006719628 XM_006719629
HUGO HGNC:20064
OMIM 610993
CCDS CCDS9053
HPRD 15636
IMGT
EMBL AC018475 AK315697 AL136825 BC030704 CH471054
GenPept AAH30704 BAG38060 CAB66759 EAW97540 EAW97541 EAW97542
RNA Seq Atlas 84101

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca