Version 5.4
Homo sapiens Gene: NDUFB4
Summary
InnateDB Gene IDBG-51806.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NDUFB4
Gene Name NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 4, 15kDa
Synonyms B15; CI-B15
Species Homo sapiens
Ensembl Gene ENSG00000065518
Encoded Proteins
IDBP-51808
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 4, 15kDa
IDBP-483841
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 4, 15kDa
IDBP-480699
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 4, 15kDa
IDBP-483424
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 4, 15kDa
IDBP-478655
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 4, 15kDa
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a non-catalytic subunit of the multisubunit NADH:ubiquinone oxidoreductase, the first enzyme complex in the mitochondrial electron transport chain (complex I). Mammalian complex I is composed of 45 different subunits and transfers electrons from NADH to ubiquinone. [provided by RefSeq, Dec 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:120596309-120602500
Strand Forward strand
Band q13.33
Transcripts
ENST00000184266 ENSP00000184266
ENST00000485064 ENSP00000419578
ENST00000492739 ENSP00000419128
ENST00000461682 ENSP00000417714
ENST00000491335 ENSP00000417755
ENST00000496588
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
Experimentally validated
Total 14 [view]
Protein-Protein 12 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0008137 NADH dehydrogenase (ubiquinone) activity
Biological Process
GO:0006120 mitochondrial electron transport, NADH to ubiquinone
GO:0006979 response to oxidative stress
GO:0022904 respiratory electron transport chain
GO:0044237 cellular metabolic process
GO:0044281 small molecule metabolic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005634 nucleus
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005747 mitochondrial respiratory chain complex I
GO:0016021 integral component of membrane
GO:0031965 nuclear membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000022820
View Gene Order
ENSBTAG00000015892
Not yet available
Pathways
NETPATH
REACTOME
REACT_22393
Respiratory electron transport pathway
REACT_6305
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. pathway
REACT_111083
The citric acid (TCA) cycle and respiratory electron transport pathway
REACT_111217
Metabolism pathway
KEGG
hsa05010
Alzheimer's disease pathway
hsa00190
Oxidative phosphorylation pathway
hsa05012
Parkinson's disease pathway
hsa05016
Huntington's disease pathway
INOH
PID NCI
Cross-References
SwissProt O95168
TrEMBL
UniProt Splice Variant
Entrez Gene 4710
UniGene
RefSeq NM_004547 NM_001168331
HUGO HGNC:7699
OMIM 603840
CCDS CCDS2999 CCDS54630
HPRD 11955
IMGT
EMBL AC126182 AF044957 BC000855 BC070285 BC146885 BC146887 BC146927 BC146932 CH471052
GenPept AAD05421 AAH00855 AAH70285 AAI46886 AAI46888 AAI46928 AAI46933 EAW79525
RNA Seq Atlas 4710

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca