Homo sapiens Gene: HAL
Summary
InnateDB Gene IDBG-51903.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HAL
Gene Name histidine ammonia-lyase
Synonyms HIS; HSTD;
Species Homo sapiens
Ensembl Gene ENSG00000084110
Encoded Proteins
histidine ammonia-lyase
histidine ammonia-lyase
histidine ammonia-lyase
histidine ammonia-lyase
histidine ammonia-lyase
histidine ammonia-lyase
histidine ammonia-lyase
histidine ammonia-lyase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Histidine ammonia-lyase is a cytosolic enzyme catalyzing the first reaction in histidine catabolism, the nonoxidative deamination of L-histidine to trans-urocanic acid. Histidine ammonia-lyase defects cause histidinemia which is characterized by increased histidine and histamine and decreased urocanic acid in body fluids. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:95972662-95996365
Strand Reverse strand
Band q23.1
Transcripts
ENST00000261208 ENSP00000261208
ENST00000544080 ENSP00000439385
ENST00000538703 ENSP00000440861
ENST00000546999 ENSP00000447675
ENST00000548808 ENSP00000446678
ENST00000548636
ENST00000552509 ENSP00000450372
ENST00000551562
ENST00000549376
ENST00000546579 ENSP00000447543
ENST00000541929 ENSP00000446364
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 3 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004397 histidine ammonia-lyase activity
GO:0016841 ammonia-lyase activity
Biological Process
GO:0006548 histidine catabolic process
GO:0009058 biosynthetic process
GO:0019556 histidine catabolic process to glutamate and formamide
GO:0019557 histidine catabolic process to glutamate and formate
GO:0034641 cellular nitrogen compound metabolic process
GO:0044281 small molecule metabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Histidine catabolism pathway
Metabolism of amino acids and derivatives pathway
Metabolism pathway
KEGG
Histidine metabolism pathway
INOH
Histidine degradation pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt P42357
TrEMBL Q2PH56
UniProt Splice Variant
Entrez Gene 3034
UniGene Hs.190783 Hs.742210
RefSeq NM_001258333 NM_001258334 NM_002108
HUGO HGNC:4806
OMIM 609457
CCDS CCDS58264 CCDS58265 CCDS9058
HPRD 07187
IMGT
EMBL AB042217 AB191166 AC007298 AC126174 AK298736 AK303544 BC096097 BC096098 BC096099 CH471054 D16626
GenPept AAH96097 AAH96098 AAH96099 BAA04047 BAB61863 BAE72115 BAG60883 BAG64570 EAW97556
RNA Seq Atlas 3034