Version 5.4
Homo sapiens Gene: SLC3A2
Summary
InnateDB Gene IDBG-52050.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLC3A2
Gene Name solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2
Synonyms 4F2; 4F2HC; 4T2HC; CD98; CD98HC; MDU1; NACAE
Species Homo sapiens
Ensembl Gene ENSG00000168003
Encoded Proteins
IDBP-52054
solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2
IDBP-52056
solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2
IDBP-52058
solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2
IDBP-52060
solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2
IDBP-589471
solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2
IDBP-587795
solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2
IDBP-583697
solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2
IDBP-602441
solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2
IDBP-599364
solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2
IDBP-596460
solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2
IDBP-584688
solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2
IDBP-600240
solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2
IDBP-590422
solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a member of the solute carrier family and encodes a cell surface, transmembrane protein. The protein exists as the heavy chain of a heterodimer, covalently bound through di-sulfide bonds to one of several possible light chains. The encoded transporter plays a role in regulation of intracellular calcium levels and transports L-type amino acids. Alternatively spliced transcript variants, encoding different isoforms, have been characterized. [provided by RefSeq, Nov 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:62856102-62888875
Strand Forward strand
Band q12.3
Transcripts
ENST00000377891 ENSP00000367123
ENST00000377890 ENSP00000367122
ENST00000377889 ENSP00000367121
ENST00000338663 ENSP00000340815
ENST00000457660
ENST00000535296 ENSP00000444236
ENST00000538084 ENSP00000440001
ENST00000544377 ENSP00000442135
ENST00000541372 ENSP00000444250
ENST00000539458 ENSP00000438032
ENST00000537508
ENST00000541649
ENST00000537839
ENST00000539891 ENSP00000438353
ENST00000538682
ENST00000546253
ENST00000536981 ENSP00000444439
ENST00000546312
ENST00000541425 ENSP00000445858
ENST00000542922
ENST00000535768
ENST00000539507 ENSP00000440819
ENST00000542793
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 43 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 43 [view]
Protein-Protein 41 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003725 double-stranded RNA binding
GO:0003824 catalytic activity
GO:0005432 calcium:sodium antiporter activity
GO:0005515 protein binding
GO:0015175 neutral amino acid transmembrane transporter activity
GO:0043169 cation binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006811 ion transport
GO:0006816 calcium ion transport
GO:0006865 amino acid transport
GO:0007596 blood coagulation
GO:0008152 metabolic process
GO:0015804 neutral amino acid transport
GO:0015827 tryptophan transport
GO:0016049 cell growth
GO:0035725 sodium ion transmembrane transport
GO:0043330 response to exogenous dsRNA
GO:0050900 leukocyte migration
GO:0055085 transmembrane transport
GO:0060356 leucine import
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016324 apical plasma membrane
GO:0030054 cell junction
GO:0042470 melanosome
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000010095
View Gene Order
ENSBTAG00000013240
Not yet available
Pathways
NETPATH
REACTOME
REACT_12560
Basigin interactions pathway
REACT_12051
Cell surface interactions at the vascular wall pathway
REACT_13796
Amino acid transport across the plasma membrane pathway
REACT_19397
Transport of inorganic cations/anions and amino acids/oligopeptides pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_19118
SLC-mediated transmembrane transport pathway
REACT_604
Hemostasis pathway
KEGG
hsa04974
Protein digestion and absorption pathway
INOH
PID NCI
nfat_tfpathway
Calcineurin-regulated NFAT-dependent transcription in lymphocytes
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.502769
RefSeq NM_001012662 NM_001012664 NM_001013251 NM_002394
HUGO
OMIM
CCDS CCDS31588 CCDS31589 CCDS31590 CCDS8039
HPRD 01148
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca