Homo sapiens Gene: KPNA1
Summary
InnateDB Gene IDBG-52534.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KPNA1
Gene Name karyopherin alpha 1 (importin alpha 5)
Synonyms IPOA5; NPI-1; RCH2; SRP1;
Species Homo sapiens
Ensembl Gene ENSG00000114030
Encoded Proteins
karyopherin alpha 1 (importin alpha 5)
karyopherin alpha 1 (importin alpha 5)
karyopherin alpha 1 (importin alpha 5)
karyopherin alpha 1 (importin alpha 5)
karyopherin alpha 1 (importin alpha 5)
karyopherin alpha 1 (importin alpha 5)
karyopherin alpha 1 (importin alpha 5)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
KPNA1 (IPOA5) regulates the import of STAT proteins into the nucleus through nuclear pores.
KPNA1 contains a nuclear localization signal binding site for STAT1 homodimers, STAT1-STAT2 heterodimers and influenza A virus nucleoprotein.
Entrez Gene
Summary The transport of molecules between the nucleus and the cytoplasm in eukaryotic cells is mediated by the nuclear pore complex (NPC), which consists of 60-100 proteins. Small molecules (up to 70 kD) can pass through the nuclear pore by nonselective diffusion while larger molecules are transported by an active process. The protein encoded by this gene belongs to the importin alpha family, and is involved in nuclear protein import. This protein interacts with the recombination activating gene 1 (RAG1) protein and is a putative substrate of the RAG1 ubiquitin ligase. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:122421949-122514945
Strand Reverse strand
Band q21.1
Transcripts
ENST00000344337 ENSP00000343701
ENST00000470904
ENST00000466923
ENST00000485027 ENSP00000420013
ENST00000494339 ENSP00000418394
ENST00000465882 ENSP00000419890
ENST00000464940
ENST00000482287 ENSP00000417166
ENST00000476916 ENSP00000417319
ENST00000493510 ENSP00000419257
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 86 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 86 [view]
Protein-Protein 86 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005488 binding
GO:0005515 protein binding
GO:0008139 nuclear localization sequence binding
GO:0008565 protein transporter activity
Biological Process
GO:0000018 regulation of DNA recombination
GO:0006309 apoptotic DNA fragmentation
GO:0006606 protein import into nucleus
GO:0006607 NLS-bearing protein import into nucleus
GO:0006915 apoptotic process
GO:0006921 cellular component disassembly involved in execution phase of apoptosis
GO:0016032 viral process
GO:0019058 viral life cycle
GO:0019221 cytokine-mediated signaling pathway
GO:0042307 positive regulation of protein import into nucleus
GO:0045087 innate immune response (InnateDB)
GO:0075733 intracellular transport of virus
Cellular Component
GO:0005634 nucleus
GO:0005643 nuclear pore
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0030425 dendrite
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Apoptotic execution phase pathway
Influenza Infection pathway
Interactions of Vpr with host cellular proteins pathway
Integration of provirus pathway
Vpr-mediated nuclear import of PICs pathway
Apoptosis induced DNA fragmentation pathway
Antiviral mechanism by IFN-stimulated genes pathway
Cytokine Signaling in Immune system pathway
Transport of Ribonucleoproteins into the Host Nucleus pathway
Activation of DNA fragmentation factor pathway
Apoptosis pathway
Interferon Signaling pathway
Early Phase of HIV Life Cycle pathway
Immune System pathway
HIV Life Cycle pathway
HIV Infection pathway
ISG15 antiviral mechanism pathway
Influenza Life Cycle pathway
Host Interactions of HIV factors pathway
Disease pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Class I PI3K signaling events mediated by Akt
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.161008 Hs.598605 Hs.610402
RefSeq NM_002264 XM_005247437
HUGO
OMIM
CCDS CCDS3013
HPRD 02819
IMGT
EMBL
GenPept
RNA Seq Atlas