InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: KPNA1

Summary

InnateDB Gene

IDBG-52534.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KPNA1

Gene Name

karyopherin alpha 1 (importin alpha 5)

Synonyms

IPOA5; NPI-1; RCH2; SRP1

Species

Homo sapiens

Ensembl Gene

ENSG00000114030

Encoded Proteins

IDBP-52536

karyopherin alpha 1 (importin alpha 5)

IDBP-474735

karyopherin alpha 1 (importin alpha 5)

IDBP-482307

karyopherin alpha 1 (importin alpha 5)

IDBP-476667

karyopherin alpha 1 (importin alpha 5)

IDBP-475754

karyopherin alpha 1 (importin alpha 5)

IDBP-483990

karyopherin alpha 1 (importin alpha 5)

IDBP-476688

karyopherin alpha 1 (importin alpha 5)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 16298512

KPNA1 (IPOA5) regulates the import of STAT proteins into the nucleus through nuclear pores.

PMID 12740372

KPNA1 contains a nuclear localization signal binding site for STAT1 homodimers, STAT1-STAT2 heterodimers and influenza A virus nucleoprotein.

Entrez Gene

Summary

The transport of molecules between the nucleus and the cytoplasm in eukaryotic cells is mediated by the nuclear pore complex (NPC), which consists of 60-100 proteins. Small molecules (up to 70 kD) can pass through the nuclear pore by nonselective diffusion while larger molecules are transported by an active process. The protein encoded by this gene belongs to the importin alpha family, and is involved in nuclear protein import. This protein interacts with the recombination activating gene 1 (RAG1) protein and is a putative substrate of the RAG1 ubiquitin ligase. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:122421949-122514945

Strand

Reverse strand

Band

q21.1

Transcripts

ENST00000344337	ENSP00000343701
ENST00000470904
ENST00000466923
ENST00000485027	ENSP00000420013
ENST00000494339	ENSP00000418394
ENST00000465882	ENSP00000419890
ENST00000464940
ENST00000482287	ENSP00000417166
ENST00000476916	ENSP00000417319
ENST00000493510	ENSP00000419257

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 86 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	86 [view]
Protein-Protein	86 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005488	binding
GO:0005515	protein binding
GO:0008139	nuclear localization sequence binding
GO:0008565	protein transporter activity

Biological Process

GO:0000018	regulation of DNA recombination
GO:0006309	apoptotic DNA fragmentation
GO:0006606	protein import into nucleus
GO:0006607	NLS-bearing protein import into nucleus
GO:0006915	apoptotic process
GO:0006921	cellular component disassembly involved in execution phase of apoptosis
GO:0016032	viral process
GO:0019058	viral life cycle
GO:0019221	cytokine-mediated signaling pathway
GO:0042307	positive regulation of protein import into nucleus
GO:0045087	innate immune response (InnateDB)
GO:0075733	intracellular transport of virus