Homo sapiens Gene: FBXO25
Summary
InnateDB Gene IDBG-5270.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FBXO25
Gene Name F-box protein 25
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000147364
Encoded Proteins
F-box protein 25
F-box protein 25
F-box protein 25
F-box protein 25
F-box protein 25
F-box protein 25
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. Three alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:406428-477967
Strand Forward strand
Band p23.3
Transcripts
ENST00000276326 ENSP00000276326
ENST00000350302 ENSP00000342077
ENST00000352684 ENSP00000341345
ENST00000382824 ENSP00000372274
ENST00000518240 ENSP00000428872
ENST00000524125
ENST00000524015
ENST00000519376
ENST00000517464
ENST00000519274 ENSP00000430191
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 194 experimentally validated interaction(s) in this database.
Experimentally validated
Total 194 [view]
Protein-Protein 194 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
Biological Process
GO:0016567 protein ubiquitination
Cellular Component
GO:0000151 ubiquitin ligase complex
GO:0005634 nucleus
GO:0019005 SCF ubiquitin ligase complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt Q8TCJ0
TrEMBL E5RFH9 H0YBS4
UniProt Splice Variant
Entrez Gene 26260
UniGene Hs.438454 Hs.596362 Hs.605765
RefSeq NM_183421 XM_005266029 NM_183420 NM_012173 XM_005266030
HUGO HGNC:13596
OMIM 609098
CCDS CCDS5953 CCDS5954 CCDS5952
HPRD 16439
IMGT
EMBL AB070270 AC083964 AF174605 AF419858 BC020249 BC050393
GenPept AAF04526 AAH20249 AAH50393 AAP97293 BAB85128
RNA Seq Atlas 26260