Version 5.4
Homo sapiens Gene: WDPCP
Summary
InnateDB Gene IDBG-53680.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol WDPCP
Gene Name WD repeat containing planar cell polarity effector
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000143951
Encoded Proteins
IDBP-53682
WD repeat containing planar cell polarity effector
IDBP-232822
WD repeat containing planar cell polarity effector
IDBP-293040
WD repeat containing planar cell polarity effector
IDBP-293038
WD repeat containing planar cell polarity effector
IDBP-293043
WD repeat containing planar cell polarity effector
IDBP-293041
WD repeat containing planar cell polarity effector
IDBP-377664
WD repeat containing planar cell polarity effector
IDBP-377665
WD repeat containing planar cell polarity effector
IDBP-377666
WD repeat containing planar cell polarity effector
IDBP-481465
WD repeat containing planar cell polarity effector
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a cytoplasmic WD40 repeat protein. A similar gene in frogs encodes a planar cell polarity protein that plays a critical role in collective cell movement and ciliogenesis by mediating septin localization. Mutations in this gene are associated with Bardet-Biedl syndrome 15 and may also play a role in Meckel-Gruber syndrome. [provided by RefSeq, Feb 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:63121383-63827843
Strand Reverse strand
Band p15
Transcripts
ENST00000272321 ENSP00000272321
ENST00000398544 ENSP00000381552
ENST00000409354 ENSP00000386795
ENST00000409199 ENSP00000386592
ENST00000409120 ENSP00000386769
ENST00000409562 ENSP00000387222
ENST00000409835
ENST00000417238 ENSP00000411429
ENST00000418148 ENSP00000409982
ENST00000431065 ENSP00000396226
ENST00000487280
ENST00000462652
ENST00000493315
ENST00000473678 ENSP00000430288
ENST00000490935
ENST00000467687
ENST00000484073
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0001822 kidney development
GO:0002093 auditory receptor cell morphogenesis
GO:0007224 smoothened signaling pathway
GO:0007399 nervous system development
GO:0010762 regulation of fibroblast migration
GO:0016476 regulation of embryonic cell shape
GO:0032185 septin cytoskeleton organization
GO:0032880 regulation of protein localization
GO:0042384 cilium assembly
GO:0042733 embryonic digit morphogenesis
GO:0043010 camera-type eye development
GO:0044782 cilium organization
GO:0045184 establishment of protein localization
GO:0048568 embryonic organ development
GO:0051893 regulation of focal adhesion assembly
GO:0055123 digestive system development
GO:0060021 palate development
GO:0060271 cilium morphogenesis
GO:0060541 respiratory system development
GO:0072358 cardiovascular system development
GO:0090521 glomerular visceral epithelial cell migration
GO:1900027 regulation of ruffle assembly
GO:2000114 regulation of establishment of cell polarity
Cellular Component
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0005930 axoneme
GO:0005938 cell cortex
GO:0016324 apical plasma membrane
GO:0097541 axonemal basal plate
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000020319
View Gene Order
ENSBTAG00000005151
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.414952 Hs.664862
RefSeq NM_001042692 NM_015910 XM_005264350
HUGO
OMIM
CCDS CCDS42688 CCDS46301
HPRD 14228
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca