Homo sapiens Gene: POU2F2
Summary
InnateDB Gene IDBG-53773.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol POU2F2
Gene Name POU class 2 homeobox 2
Synonyms Oct-2; OCT2; OTF2;
Species Homo sapiens
Ensembl Gene ENSG00000028277
Encoded Proteins
POU class 2 homeobox 2
POU class 2 homeobox 2
POU class 2 homeobox 2
POU class 2 homeobox 2
POU class 2 homeobox 2
POU class 2 homeobox 2
POU class 2 homeobox 2
POU class 2 homeobox 2
POU class 2 homeobox 2
POU class 2 homeobox 2
POU class 2 homeobox 2
POU class 2 homeobox 2
POU class 2 homeobox 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a homeobox-containing transcription factor of the POU domain family. The encoded protein binds the octamer sequence 5'-ATTTGCAT-3', a common transcription factor binding site in immunoglobulin gene promoters. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
The protein encoded by this gene is a homeobox-containing transcription factor of the POU domain family. The encoded protein binds the octamer sequence 5\'-ATTTGCAT-3\', a common transcription factor binding site in immunoglobulin gene promoters. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:42086110-42196585
Strand Reverse strand
Band q13.2
Transcripts
ENST00000342301 ENSP00000339369
ENST00000389341 ENSP00000373992
ENST00000560804 ENSP00000452930
ENST00000526816 ENSP00000431603
ENST00000529067 ENSP00000437224
ENST00000534559 ENSP00000436100
ENST00000533548 ENSP00000453995
ENST00000560558 ENSP00000454179
ENST00000560398 ENSP00000453255
ENST00000529952 ENSP00000436988
ENST00000528894 ENSP00000475664
ENST00000526831 ENSP00000476062
ENST00000530982
ENST00000531773
ENST00000524801
ENST00000532176
ENST00000558596 ENSP00000476240
ENST00000598842 ENSP00000471890
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 21 [view]
Protein-Protein 19 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0019904 protein domain specific binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0002335 mature B cell differentiation
GO:0002380 immunoglobulin secretion involved in immune response
GO:0006355 regulation of transcription, DNA-templated
GO:0006366 transcription from RNA polymerase II promoter
GO:0006959 humoral immune response
GO:0045893 positive regulation of transcription, DNA-templated
GO:0048305 immunoglobulin secretion
GO:0048469 cell maturation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
KEGG
INOH
PID BIOCARTA
PID NCI
BCR signaling pathway
Validated transcriptional targets of deltaNp63 isoforms
Cross-References
SwissProt
TrEMBL H0YNW1 Q9UMI6 Q9UMJ4
UniProt Splice Variant
Entrez Gene 5452
UniGene Hs.601322 Hs.604769
RefSeq NM_002698 NM_001207025 NM_001247994 NM_001207026
HUGO HGNC:9213
OMIM 164176
CCDS CCDS33035 CCDS56095 CCDS58665 CCDS56094
HPRD 01251
IMGT
EMBL AC010247 AC022515 AC024076 M22596 M36772
GenPept AAA36392 AAA64232
RNA Seq Atlas 5452