InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: POU2F2

Summary

InnateDB Gene

IDBG-53773.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

POU2F2

Gene Name

POU class 2 homeobox 2

Synonyms

Oct-2; OCT2; OTF2

Species

Homo sapiens

Ensembl Gene

ENSG00000028277

Encoded Proteins

IDBP-53775

POU class 2 homeobox 2

IDBP-53781

POU class 2 homeobox 2

IDBP-591695

POU class 2 homeobox 2

IDBP-596944

POU class 2 homeobox 2

IDBP-593878

POU class 2 homeobox 2

IDBP-584480

POU class 2 homeobox 2

IDBP-594216

POU class 2 homeobox 2

IDBP-583671

POU class 2 homeobox 2

IDBP-602325

POU class 2 homeobox 2

IDBP-589945

POU class 2 homeobox 2

IDBP-806687

POU class 2 homeobox 2

IDBP-806688

POU class 2 homeobox 2

IDBP-806692

POU class 2 homeobox 2

IDBP-765282

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is a homeobox-containing transcription factor of the POU domain family. The encoded protein binds the octamer sequence 5'-ATTTGCAT-3', a common transcription factor binding site in immunoglobulin gene promoters. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
The protein encoded by this gene is a homeobox-containing transcription factor of the POU domain family. The encoded protein binds the octamer sequence 5\'-ATTTGCAT-3\', a common transcription factor binding site in immunoglobulin gene promoters. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:42086110-42196585

Strand

Reverse strand

Band

q13.2

Transcripts

ENST00000342301	ENSP00000339369
ENST00000389341	ENSP00000373992
ENST00000560804	ENSP00000452930
ENST00000526816	ENSP00000431603
ENST00000529067	ENSP00000437224
ENST00000534559	ENSP00000436100
ENST00000533548	ENSP00000453995
ENST00000560558	ENSP00000454179
ENST00000560398	ENSP00000453255
ENST00000529952	ENSP00000436988
ENST00000528894	ENSP00000475664
ENST00000526831	ENSP00000476062
ENST00000530982
ENST00000531773
ENST00000524801
ENST00000532176
ENST00000558596	ENSP00000476240
ENST00000598842	ENSP00000471890

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	21 [view]
Protein-Protein	19 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0019904	protein domain specific binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0002335	mature B cell differentiation
GO:0002380	immunoglobulin secretion involved in immune response
GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0006959	humoral immune response
GO:0045893	positive regulation of transcription, DNA-templated
GO:0048305	immunoglobulin secretion
GO:0048469	cell maturation

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000008496

View Gene Order

ENSBTAG00000008556

Not yet available

Pathways

NETPATH

REACTOME

KEGG

INOH

PID NCI

bcr_5pathway

BCR signaling pathway

deltanp63pathway

Validated transcriptional targets of deltaNp63 isoforms

Cross-References

SwissProt

TrEMBL

H0YKT2 Q9UMJ4

UniProt Splice Variant

Entrez Gene

5452

UniGene

Hs.601322 Hs.604769

RefSeq

NM_001207025 NM_001207026 NM_001247994 NM_002698

HUGO

HGNC:9213

OMIM

164176

CCDS

CCDS33035 CCDS56094 CCDS56095 CCDS58665

HPRD

01251

IMGT

EMBL

AC010247 AC022515 AC024076 M22596

GenPept

AAA64232

RNA Seq Atlas

5452