Homo sapiens Gene: LIPE
Summary
InnateDB Gene IDBG-54295.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LIPE
Gene Name lipase, hormone-sensitive
Synonyms AOMS4; HSL; LHS;
Species Homo sapiens
Ensembl Gene ENSG00000079435
Encoded Proteins
lipase, hormone-sensitive
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene has a long and a short form, generated by use of alternative translational start codons. The long form is expressed in steroidogenic tissues such as testis, where it converts cholesteryl esters to free cholesterol for steroid hormone production. The short form is expressed in adipose tissue, among others, where it hydrolyzes stored triglycerides to free fatty acids. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:42401507-42427426
Strand Reverse strand
Band q13.2
Transcripts
ENST00000244289 ENSP00000244289
ENST00000599918 ENSP00000472218
ENST00000597620 ENSP00000469545
ENST00000597001 ENSP00000469268
ENST00000601189 ENSP00000469030
ENST00000600224
ENST00000602000
ENST00000599211 ENSP00000472531
ENST00000599783 ENSP00000469990
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004806 triglyceride lipase activity
GO:0005515 protein binding
GO:0016298 lipase activity
GO:0016787 hydrolase activity
GO:0019901 protein kinase binding
GO:0033878 hormone-sensitive lipase activity
Biological Process
GO:0006468 protein phosphorylation
GO:0008152 metabolic process
GO:0008203 cholesterol metabolic process
GO:0016042 lipid catabolic process
GO:0019433 triglyceride catabolic process
GO:0042758 long-chain fatty acid catabolic process
GO:0044281 small molecule metabolic process
GO:0046340 diacylglycerol catabolic process
Cellular Component
GO:0005811 lipid particle
GO:0005829 cytosol
GO:0005901 caveola
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Metabolism of lipids and lipoproteins pathway
Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis pathway
Metabolism pathway
Lipid digestion, mobilization, and transport pathway
KEGG
Insulin signaling pathway pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL M0QXB1 M0QXM5 M0QYP8
UniProt Splice Variant
Entrez Gene 3991
UniGene Hs.656980
RefSeq NM_005357 XM_005258939 XM_005258940 XM_005258941 XM_006723218
HUGO HGNC:6621
OMIM 151750
CCDS CCDS12607
HPRD 01062
IMGT
EMBL AC011497
GenPept
RNA Seq Atlas 3991