Homo sapiens Gene: NRXN2
Summary
InnateDB Gene IDBG-54301.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NRXN2
Gene Name neurexin 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000110076
Encoded Proteins
neurexin 2
neurexin 2
neurexin 2
neurexin 2
neurexin 2
neurexin 2
neurexin 2
neurexin 2
neurexin 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the neurexin gene family. The products of these genes function as cell adhesion molecules and receptors in the vertebrate nervous system. These genes utilize two promoters. The majority of transcripts are produced from the upstream promoter and encode alpha-neurexin isoforms while a smaller number of transcripts are produced from the downstream promoter and encode beta-neuresin isoforms. The alpha-neurexins contain epidermal growth factor-like (EGF-like) sequences and laminin G domains, and have been shown to interact with neurexophilins. The beta-neurexins lack EGF-like sequences and contain fewer laminin G domains than alpha-neurexins. Alternative splicing and the use of alternative promoters may generate thousands of transcript variants (PMID: 12036300, PMID: 11944992).[provided by RefSeq, Jun 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:64606174-64723188
Strand Reverse strand
Band q13.1
Transcripts
ENST00000377559 ENSP00000366782
ENST00000377551 ENSP00000366774
ENST00000265459 ENSP00000265459
ENST00000301894 ENSP00000301894
ENST00000409571 ENSP00000386416
ENST00000423049 ENSP00000407374
ENST00000442300 ENSP00000388971
ENST00000417749 ENSP00000411271
ENST00000437746 ENSP00000412211
ENST00000464307
ENST00000475737
ENST00000467055
ENST00000487484
ENST00000486057
ENST00000496291
ENST00000466324
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005246 calcium channel regulator activity
GO:0005515 protein binding
GO:0046872 metal ion binding
GO:0050839 cell adhesion molecule binding
GO:0097109 neuroligin family protein binding
Biological Process
GO:0007158 neuron cell-cell adhesion
GO:0007268 synaptic transmission
GO:0007269 neurotransmitter secretion
GO:0007416 synapse assembly
GO:0030534 adult behavior
GO:0035176 social behavior
GO:0042297 vocal learning
GO:0071625 vocalization behavior
GO:0097104 postsynaptic membrane assembly
GO:0097116 gephyrin clustering
GO:0097118 neuroligin clustering
GO:0097119 postsynaptic density protein 95 clustering
Cellular Component
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
Cell adhesion molecules (CAMs) pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q9P2S2
TrEMBL
UniProt Splice Variant
Entrez Gene 9379
UniGene Hs.372938
RefSeq NM_015080 NM_138732 NM_138734 XM_005274406 XM_006718747 XM_006718746 XM_006718744 XM_006718743 XM_006718742 XM_005274400
HUGO HGNC:8009
OMIM 600566
CCDS CCDS8077 CCDS31597 CCDS8078
HPRD 11859
IMGT
EMBL AB023138 AB035266 AC044790 BC150275
GenPept AAI50276 AAK68154 BAA76765 BAA94075
RNA Seq Atlas 9379