InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: NRXN2

Summary

InnateDB Gene

IDBG-54301.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NRXN2

Gene Name

neurexin 2

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000110076

Encoded Proteins

IDBP-54305

neurexin 2

IDBP-54307

neurexin 2

IDBP-54311

neurexin 2

IDBP-54313

neurexin 2

IDBP-295237

neurexin 2

IDBP-377477

neurexin 2

IDBP-377478

neurexin 2

IDBP-377480

neurexin 2

IDBP-377482

neurexin 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the neurexin gene family. The products of these genes function as cell adhesion molecules and receptors in the vertebrate nervous system. These genes utilize two promoters. The majority of transcripts are produced from the upstream promoter and encode alpha-neurexin isoforms while a smaller number of transcripts are produced from the downstream promoter and encode beta-neuresin isoforms. The alpha-neurexins contain epidermal growth factor-like (EGF-like) sequences and laminin G domains, and have been shown to interact with neurexophilins. The beta-neurexins lack EGF-like sequences and contain fewer laminin G domains than alpha-neurexins. Alternative splicing and the use of alternative promoters may generate thousands of transcript variants (PMID: 12036300, PMID: 11944992).[provided by RefSeq, Jun 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:64606174-64723188

Strand

Reverse strand

Band

q13.1

Transcripts

ENST00000377559	ENSP00000366782
ENST00000377551	ENSP00000366774
ENST00000265459	ENSP00000265459
ENST00000301894	ENSP00000301894
ENST00000409571	ENSP00000386416
ENST00000423049	ENSP00000407374
ENST00000442300	ENSP00000388971
ENST00000417749	ENSP00000411271
ENST00000437746	ENSP00000412211
ENST00000464307
ENST00000475737
ENST00000467055
ENST00000487484
ENST00000486057
ENST00000496291
ENST00000466324

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005246	calcium channel regulator activity
GO:0005515	protein binding
GO:0046872	metal ion binding
GO:0050839	cell adhesion molecule binding
GO:0097109	neuroligin family protein binding

Biological Process

GO:0007158	neuron cell-cell adhesion
GO:0007268	synaptic transmission
GO:0007269	neurotransmitter secretion
GO:0007416	synapse assembly
GO:0030534	adult behavior
GO:0035176	social behavior
GO:0042297	vocal learning
GO:0071625	vocalization behavior
GO:0097104	postsynaptic membrane assembly
GO:0097116	gephyrin clustering
GO:0097118	neuroligin clustering
GO:0097119	postsynaptic density protein 95 clustering

Cellular Component

GO:0016021

integral component of membrane

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000033768

View Gene Order

ENSBTAG00000000244

Not yet available

Pathways

NETPATH

REACTOME

KEGG

hsa04514

Cell adhesion molecules (CAMs) pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.372938

RefSeq

NM_015080 NM_138732 NM_138734 XM_005274400 XM_005274406 XM_006718742 XM_006718743 XM_006718744 XM_006718746 XM_006718747

HUGO

OMIM

CCDS

CCDS31597 CCDS8077 CCDS8078

HPRD

11859

IMGT

EMBL

GenPept

RNA Seq Atlas