Version 5.4
Homo sapiens Gene: ALDH1L1
Summary
InnateDB Gene IDBG-54444.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ALDH1L1
Gene Name aldehyde dehydrogenase 1 family, member L1
Synonyms 10-fTHF; 10-FTHFDH; FDH; FTHFD
Species Homo sapiens
Ensembl Gene ENSG00000144908
Encoded Proteins
IDBP-54446
aldehyde dehydrogenase 1 family, member L1
IDBP-243626
aldehyde dehydrogenase 1 family, member L1
IDBP-243628
aldehyde dehydrogenase 1 family, member L1
IDBP-383446
aldehyde dehydrogenase 1 family, member L1
IDBP-383447
aldehyde dehydrogenase 1 family, member L1
IDBP-480667
aldehyde dehydrogenase 1 family, member L1
IDBP-481411
aldehyde dehydrogenase 1 family, member L1
IDBP-475311
aldehyde dehydrogenase 1 family, member L1
IDBP-476301
aldehyde dehydrogenase 1 family, member L1
IDBP-482220
aldehyde dehydrogenase 1 family, member L1
IDBP-476671
aldehyde dehydrogenase 1 family, member L1
IDBP-481800
aldehyde dehydrogenase 1 family, member L1
IDBP-476965
aldehyde dehydrogenase 1 family, member L1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene catalyzes the conversion of 10-formyltetrahydrofolate, nicotinamide adenine dinucleotide phosphate (NADP+), and water to tetrahydrofolate, NADPH, and carbon dioxide. The encoded protein belongs to the aldehyde dehydrogenase family. Loss of function or expression of this gene is associated with decreased apoptosis, increased cell motility, and cancer progression. There is an antisense transcript that overlaps on the opposite strand with this gene locus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:126103562-126197994
Strand Reverse strand
Band q21.3
Transcripts
ENST00000273450 ENSP00000273450
ENST00000393434 ENSP00000377083
ENST00000393431 ENSP00000377081
ENST00000455064 ENSP00000414126
ENST00000452905 ENSP00000395881
ENST00000413612
ENST00000472186 ENSP00000420293
ENST00000467370
ENST00000462808
ENST00000476245
ENST00000473607 ENSP00000419448
ENST00000484724
ENST00000493803 ENSP00000418905
ENST00000490367 ENSP00000418711
ENST00000460368 ENSP00000419826
ENST00000488356 ENSP00000419955
ENST00000509952 ENSP00000426594
ENST00000511283 ENSP00000426713
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0005515 protein binding
GO:0008168 methyltransferase activity
GO:0016155 formyltetrahydrofolate dehydrogenase activity
GO:0016491 oxidoreductase activity
GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
GO:0016742 hydroxymethyl-, formyl- and related transferase activity
Biological Process
GO:0006730 one-carbon metabolic process
GO:0008152 metabolic process
GO:0009058 biosynthetic process
GO:0009258 10-formyltetrahydrofolate catabolic process
GO:0032259 methylation
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000030088
View Gene Order
ENSBTAG00000014470
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa00670
One carbon pool by folate pathway
INOH
INOH website
Folate metabolism pathway
PID NCI
Cross-References
SwissProt
TrEMBL F2Z324
UniProt Splice Variant
Entrez Gene 10840
UniGene Hs.434435 Hs.706316 Hs.742339
RefSeq NM_001270364 NM_001270365 NM_012190 XM_006713481 XM_006713482
HUGO HGNC:3978
OMIM 600249
CCDS CCDS3034 CCDS58850 CCDS58851
HPRD 02594
IMGT
EMBL AC079848
GenPept
RNA Seq Atlas 102723653 10840

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca