Version 5.4
| Homo sapiens Gene: KIAA0391 | |||
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| Summary | |||
| InnateDB Gene | IDBG-545199.3 | ||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||
| Gene Symbol | KIAA0391 | ||
| Gene Name | KIAA0391 | ||
| Synonyms | IOTA; MRPP3; p27K; PRORP; PROS27 | ||
| Species | Homo sapiens | ||
| Ensembl Gene | ENSG00000258790 | ||
| Encoded Proteins | |||
| Protein Structure | |||
| Useful resources | Stemformatics EHFPI ImmGen | ||
| Entrez Gene | |||
| Summary |
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. Multiple transcript variants encoding several different isoforms have been found for this gene. A pseudogene has been identified on the Y chromosome. [provided by RefSeq, Aug 2013] |
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| Gene Information | |||
| Type | Protein coding | ||
| Genomic Location | Chromosome 14:35122549-35317474 | ||
| Strand | Forward strand | ||
| Band | q13.2 | ||
| Transcripts |
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| Interactions | |||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||
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Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Pathways | |||
| NETPATH | |||
| REACTOME | |||
| KEGG |
Proteasome pathway
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| INOH | |||
| PID NCI | |||
| Cross-References | |||
| SwissProt | |||
| TrEMBL | S4R3S1 S4R3T4 S4R416 | ||
| UniProt Splice Variant | |||
| Entrez Gene | 9692 | ||
| UniGene | Hs.601158 Hs.667699 Hs.707099 | ||
| RefSeq | XM_005268237 XM_006720334 | ||
| HUGO | HGNC:19958 | ||
| OMIM | 602855 609947 | ||
| CCDS | CCDS32063 | ||
| HPRD | |||
| IMGT | |||
| EMBL | AB002389 AK301931 AK303508 AK304066 AL121594 BC032221 BC044580 BX161394 BX161487 CH471078 | ||
| GenPept | AAH32221 AAH44580 BAA20845 BAG63351 BAG64540 BAG64973 CAD61881 CAD61937 EAW65878 EAW65879 EAW65880 EAW65881 EAW65882 EAW65883 EAW65884 | ||
| RNA Seq Atlas | 5687 9692 | ||