Homo sapiens Gene: PTTG1IP
Summary
InnateDB Gene IDBG-5574.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PTTG1IP
Gene Name pituitary tumor-transforming 1 interacting protein
Synonyms C21orf1; C21orf3; PBF;
Species Homo sapiens
Ensembl Gene ENSG00000183255
Encoded Proteins
pituitary tumor-transforming 1 interacting protein
pituitary tumor-transforming 1 interacting protein
pituitary tumor-transforming 1 interacting protein
pituitary tumor-transforming 1 interacting protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The encoded protein, which directly binds to pituitary tumor-transforming gene 1 protein (PTTG1), facilitates the nuclear translocation of PTTG1 and potentiates the transcriptional activation of basic fibroblast growth factor by PTTG1. The gene product localizes to both the cytoplasm and nucleus. Its NLS is required for its own nuclear localization, the nuclear localization of PTTG1, and its interaction with PTTG1. [provided by RefSeq, Jul 2008]
This gene encodes a single-pass type I integral membrane protein, which binds to pituitary tumor-transforming 1 protein (PTTG1), and facilitates translocation of PTTG1 into the nucleus. Coexpression of this protein and PTTG1 induces transcriptional activation of basic fibroblast growth factor. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 21:44849585-44873903
Strand Reverse strand
Band q22.3
Transcripts
ENST00000330938 ENSP00000328325
ENST00000397887 ENSP00000380984
ENST00000397886 ENSP00000380983
ENST00000445724 ENSP00000395374
ENST00000474737
ENST00000494690
ENST00000480234
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0004872 receptor activity
Biological Process
GO:0006606 protein import into nucleus
GO:0007275 multicellular organismal development
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
EGFR1 pathway
TCR pathway
REACTOME
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt P53801
TrEMBL A8K274 A8MXQ1 A8MZH8 B4DPZ0
UniProt Splice Variant
Entrez Gene 754
UniGene Hs.708709
RefSeq NM_001286822 NM_004339
HUGO HGNC:13524
OMIM 603784
CCDS CCDS13715 CCDS68221
HPRD
IMGT
EMBL AF149785 AK290139 AK298557 AK315626 AL163300 AL773603 BC000415 BC012858 BC019295 BC020983 BC031097 BC034250 CH471079 Z50022
GenPept AAF73770 AAH00415 AAH12858 AAH19295 AAH20983 AAH31097 AAH34250 BAF82828 BAG37994 BAG60752 CAA90325 CAB90552 EAX09386 EAX09388
RNA Seq Atlas 754