|Homo sapiens Gene: IL12B|
|Last Modified||2014-10-13 [Report errors or provide feedback]|
|Gene Name||interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)|
|Synonyms||CLMF; CLMF2; IL-12B; IMD28; IMD29; NKSF; NKSF2;|
interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)
|Useful resources||Stemformatics EHFPI ImmGen|
IL12B production in response to Toll-like receptor (TLR) stimulation is regulated by the tyrosine phosphatase activity of PTPN6 and this is a novel mechanism for host regulation of IL12, a cytokine important in both innate and adaptive immunity.
IL12, consisting of IL12A and IL12B subunits, initiates local antitumor immunity by stimulating lymphoid tissue-inducer (LTi) cells bearing the natural cytotoxicity receptor NCR1 (NKp46).
IL12, consisting of IL12A and IL12B subunits, induces IL2RA to form high-affinity IL2 receptors on natural killer cells in response to mouse cytomegalovirus infection. (Demonstrated in mouse)
Macrophages cultured with bile acids produce lower levels of IL12 and display an anti-inflammatory phenotype characterized by an increased ratio of IL10 to IL12
IFN gamma creates a primed chromatin environment in macrophages to augment TLR-induced IL12B transcription
|InnateDB Annotation from Orthologs|
[Mus musculus] Il12, consisting of Il12a and Il12b subunits, induces Il2ra to form high-affinity Il2 receptors on natural killer cells in response to mouse cytomegalovirus infection.
[Mus musculus] Nod1 and Nod2 synergize with Tlr4 in dendritic cells to increase IL12 production and enhance invariant natural killer T (iNKT) cell activation, and are important regulators of the IFN gamma response by iNKT cells during S. typhimurium and L. monocytogenes infections.
This gene encodes a subunit of interleukin 12, a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor like subunit encoded by this gene, and a 35 kD subunit encoded by IL12A. This cytokine is expressed by activated macrophages that serve as an essential inducer of Th1 cells development. This cytokine has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen. Overexpression of this gene was observed in the central nervous system of patients with multiple sclerosis (MS), suggesting a role of this cytokine in the pathogenesis of the disease. The promoter polymorphism of this gene has been reported to be associated with the severity of atopic and non-atopic asthma in children. [provided by RefSeq, Jul 2008]
|Genomic Location||Chromosome 5:159314783-159330887|
|Number of Interactions||
This gene and/or its encoded proteins are associated with 35 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.
Cytokine-cytokine receptor interaction pathway
Toll-like receptor signaling pathway pathway
RIG-I-like receptor signaling pathway pathway
Jak-STAT signaling pathway pathway
Type I diabetes mellitus pathway
Chagas disease (American trypanosomiasis) pathway
African trypanosomiasis pathway
Allograft rejection pathway
GPCR signaling pathway
IL-23 signaling pathway
JAK STAT pathway and regulation pathway
IL-12 signaling pathway
IL27-mediated signaling events
IL12-mediated signaling events
IL23-mediated signaling events
|UniProt Splice Variant|
|EMBL||AF180563 AF512686 AY008847 AY046592 AY046593 BC067498 BC067499 BC067500 BC067501 BC067502 BC074723 EF173865 M65272 M65290|
|GenPept||AAA35695 AAA59938 AAD56386 AAG32620 AAH67498 AAH67499 AAH67500 AAH67501 AAH67502 AAH74723 AAL05890 AAL05891 AAM34792 ABM53138|
|RNA Seq Atlas||3593|