Version 5.4
Homo sapiens Gene: HOXB3
Summary
InnateDB Gene IDBG-56791.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HOXB3
Gene Name homeobox B3
Synonyms Hox-2.7; HOX2; HOX2G
Species Homo sapiens
Ensembl Gene ENSG00000120093
Encoded Proteins
IDBP-56793
homeobox B3
IDBP-485092
homeobox B3
IDBP-474572
homeobox B3
IDBP-483039
homeobox B3
IDBP-602315
homeobox B3
IDBP-478614
homeobox B3
IDBP-481805
homeobox B3
IDBP-478948
homeobox B3
IDBP-479032
homeobox B3
IDBP-592531
homeobox B3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Increased expression of this gene is associated with a distinct biologic subset of acute myeloid leukemia (AML). [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:48548870-48604912
Strand Reverse strand
Band q21.32
Transcripts
ENST00000311626 ENSP00000308252
ENST00000470495 ENSP00000417207
ENST00000472863 ENSP00000419676
ENST00000498678 ENSP00000420595
ENST00000490677 ENSP00000449977
ENST00000460160 ENSP00000418035
ENST00000489475 ENSP00000418729
ENST00000476342 ENSP00000418892
ENST00000471459 ENSP00000417400
ENST00000465120 ENSP00000446783
ENST00000478644
ENST00000464266
ENST00000552000
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001525 angiogenesis
GO:0002244 hematopoietic progenitor cell differentiation
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0009952 anterior/posterior pattern specification
GO:0021546 rhombomere development
GO:0021615 glossopharyngeal nerve morphogenesis
GO:0030878 thyroid gland development
GO:0048704 embryonic skeletal system morphogenesis
GO:0050767 regulation of neurogenesis
GO:0051216 cartilage development
GO:0060216 definitive hemopoiesis
GO:0060324 face development
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000048763
View Gene Order
ENSBTAG00000021427
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.666381 Hs.687723
RefSeq NM_002146
HUGO
OMIM
CCDS CCDS11528
HPRD 00853
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca