Homo sapiens Gene: ABI3
Summary
InnateDB Gene IDBG-57525.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ABI3
Gene Name ABI family, member 3
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000108798
Encoded Proteins
ABI family, member 3
ABI family, member 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of an adaptor protein family. Members of this family encode proteins containing a homeobox homology domain, proline rich region and Src-homology 3 (SH3) domain, and are components of the Abi/WAVE complex which regulates Rac-dependent actin polymerization. The encoded protein inhibits ectopic metastasis of tumor cells as well as cell migration. This may be accomplished through interaction with p21-activated kinase. [provided by RefSeq, Sep 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:49210227-49223225
Strand Forward strand
Band q21.32
Transcripts
ENST00000225941 ENSP00000225941
ENST00000419580 ENSP00000406651
ENST00000571035 ENSP00000459171
ENST00000573347 ENSP00000460776
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
Experimentally validated
Total 23 [view]
Protein-Protein 21 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006928 cellular component movement
GO:0030334 regulation of cell migration
Cellular Component
GO:0005622 intracellular
GO:0005737 cytoplasm
GO:0016020 membrane
GO:0030027 lamellipodium
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 51225
UniGene Hs.130719 Hs.623236
RefSeq NM_001135186 NM_016428 XM_005257429
HUGO HGNC:29859
OMIM 606363
CCDS CCDS11546 CCDS45725
HPRD 05900
IMGT
EMBL
GenPept
RNA Seq Atlas 51225