InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ITGA3

Summary

InnateDB Gene

IDBG-58012.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ITGA3

Gene Name

integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)

Synonyms

CD49C; GAP-B3; GAPB3; ILNEB; MSK18; VCA-2; VL3A; VLA3a

Species

Homo sapiens

Ensembl Gene

ENSG00000005884

Encoded Proteins

IDBP-58014

integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)

IDBP-58016

integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)

IDBP-476972

integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)

IDBP-764542

IDBP-476955

integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)

IDBP-482884

integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)

IDBP-763197

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 20877569

ITGA3 along with ITGB1 is a novel regulator for the recognition of bacterial lipopeptides. ITGA3/ITGB1 integrin regulates endosomal Toll-like receptor (TLR)-2/TLR1 signalling, serving as a mechanism for modulating inflammatory responses.

Entrez Gene

Summary

The protein encoded by this gene belongs to the family of integrins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain, and function as cell surface adhesion molecules. This gene encodes alpha 3 subunit, which undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 subunit to form an integrin that interacts with many extracellular-matrix proteins. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Oct 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:50055968-50090481

Strand

Forward strand

Band

q21.33

Transcripts

ENST00000320031	ENSP00000315190
ENST00000007722	ENSP00000007722
ENST00000506401	ENSP00000422826
ENST00000505306
ENST00000508100
ENST00000512553	ENSP00000466652
ENST00000505552
ENST00000510809	ENSP00000425980
ENST00000505612
ENST00000506827	ENSP00000426142
ENST00000507771
ENST00000515147
ENST00000504417	ENSP00000467851
ENST00000506437
ENST00000514834
ENST00000570989

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	24 [view]
Protein-Protein	22 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001968	fibronectin binding
GO:0005178	integrin binding
GO:0005515	protein binding
GO:0005518	collagen binding
GO:0019904	protein domain specific binding
GO:0043236	laminin binding
GO:0046872	metal ion binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0001764	neuron migration
GO:0007155	cell adhesion
GO:0007160	cell-matrix adhesion
GO:0007229	integrin-mediated signaling pathway
GO:0007507	heart development
GO:0007596	blood coagulation
GO:0007613	memory
GO:0010628	positive regulation of gene expression
GO:0010634	positive regulation of epithelial cell migration
GO:0010811	positive regulation of cell-substrate adhesion
GO:0010976	positive regulation of neuron projection development
GO:0030198	extracellular matrix organization
GO:0031345	negative regulation of cell projection organization
GO:0034698	response to gonadotropin
GO:0042493	response to drug
GO:0045087	innate immune response (InnateDB)
GO:0050900	leukocyte migration
GO:0060135	maternal process involved in female pregnancy

Cellular Component

GO:0005886	plasma membrane
GO:0008305	integrin complex
GO:0009897	external side of plasma membrane
GO:0009986	cell surface
GO:0016021	integral component of membrane
GO:0016323	basolateral plasma membrane
GO:0030426	growth cone
GO:0034667	integrin alpha3-beta1 complex
GO:0043235	receptor complex
GO:0045202	synapse
GO:0048471	perinuclear region of cytoplasm
GO:0070062	extracellular vesicular exosome