Homo sapiens Gene: ITGA3
Summary
InnateDB Gene IDBG-58012.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ITGA3
Gene Name integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
Synonyms CD49C; GAP-B3; GAPB3; ILNEB; MSK18; VCA-2; VL3A; VLA3a;
Species Homo sapiens
Ensembl Gene ENSG00000005884
Encoded Proteins
integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
ITGA3 along with ITGB1 is a novel regulator for the recognition of bacterial lipopeptides. ITGA3/ITGB1 integrin regulates endosomal Toll-like receptor (TLR)-2/TLR1 signalling, serving as a mechanism for modulating inflammatory responses.
Entrez Gene
Summary The protein encoded by this gene belongs to the family of integrins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain, and function as cell surface adhesion molecules. This gene encodes alpha 3 subunit, which undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 subunit to form an integrin that interacts with many extracellular-matrix proteins. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Oct 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:50055968-50090481
Strand Forward strand
Band q21.33
Transcripts
ENST00000320031 ENSP00000315190
ENST00000007722 ENSP00000007722
ENST00000506401 ENSP00000422826
ENST00000505306
ENST00000508100
ENST00000512553 ENSP00000466652
ENST00000505552
ENST00000510809 ENSP00000425980
ENST00000505612
ENST00000506827 ENSP00000426142
ENST00000507771
ENST00000515147
ENST00000504417 ENSP00000467851
ENST00000506437
ENST00000514834
ENST00000570989
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 24 [view]
Protein-Protein 22 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001968 fibronectin binding
GO:0005178 integrin binding
GO:0005515 protein binding
GO:0005518 collagen binding
GO:0019904 protein domain specific binding
GO:0043236 laminin binding
GO:0046872 metal ion binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0001764 neuron migration
GO:0007155 cell adhesion
GO:0007160 cell-matrix adhesion
GO:0007229 integrin-mediated signaling pathway
GO:0007507 heart development
GO:0007596 blood coagulation
GO:0007613 memory
GO:0010628 positive regulation of gene expression
GO:0010634 positive regulation of epithelial cell migration
GO:0010811 positive regulation of cell-substrate adhesion
GO:0010976 positive regulation of neuron projection development
GO:0030198 extracellular matrix organization
GO:0031345 negative regulation of cell projection organization
GO:0034698 response to gonadotropin
GO:0042493 response to drug
GO:0045087 innate immune response (InnateDB)
GO:0050900 leukocyte migration
GO:0060135 maternal process involved in female pregnancy
Cellular Component
GO:0005886 plasma membrane
GO:0008305 integrin complex
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0016021 integral component of membrane
GO:0016323 basolateral plasma membrane
GO:0030426 growth cone
GO:0034667 integrin alpha3-beta1 complex
GO:0043235 receptor complex
GO:0045202 synapse
GO:0048471 perinuclear region of cytoplasm
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
EGFR1 pathway
REACTOME
Extracellular matrix organization pathway
Integrin cell surface interactions pathway
Basigin interactions pathway
Laminin interactions pathway
Cell surface interactions at the vascular wall pathway
Hemostasis pathway
KEGG
Focal adhesion pathway
ECM-receptor interaction pathway
Hematopoietic cell lineage pathway
Regulation of actin cytoskeleton pathway
Pathways in cancer pathway
Small cell lung cancer pathway
Hypertrophic cardiomyopathy (HCM) pathway
Arrhythmogenic right ventricular cardiomyopathy (ARVC) pathway
Dilated cardiomyopathy pathway
INOH
Integrin signaling pathway pathway
PID BIOCARTA
PID NCI
Beta1 integrin cell surface interactions
Reelin signaling pathway
Integrin family cell surface interactions
Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
IL23-mediated signaling events
Validated transcriptional targets of deltaNp63 isoforms
Validated transcriptional targets of TAp63 isoforms
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.265829
RefSeq NM_002204 NM_005501
HUGO
OMIM
CCDS CCDS11557 CCDS11558
HPRD 05431
IMGT
EMBL
GenPept
RNA Seq Atlas