Version 5.4
Homo sapiens Gene: OAS2
Summary
InnateDB Gene IDBG-58392.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol OAS2
Gene Name 2'-5'-oligoadenylate synthetase 2, 69/71kDa
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000111335
Encoded Proteins
IDBP-58394
2'-5'-oligoadenylate synthetase 2, 69/71kDa
IDBP-245370
2'-5'-oligoadenylate synthetase 2, 69/71kDa
IDBP-383625
2'-5'-oligoadenylate synthetase 2, 69/71kDa
IDBP-601343
2'-5'-oligoadenylate synthetase 2, 69/71kDa
IDBP-584199
2'-5'-oligoadenylate synthetase 2, 69/71kDa
IDBP-808625
2'-5'-oligoadenylate synthetase 2, 69/71kDa
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 21190483
OAS2 is a pathogen recognition receptor for the viral pathogen-associated molecular pattern, double-stranded RNA. Upon recognition of dsRNA, the OAS2 activates RNASEL to cleave ssRNA. The OAS/RNASEL pathway triggers the RIG-I pathway and induce IFNB production.
InnateDB Annotation from Orthologs
Summary
PMID 21190483
[Mus musculus] Oas2 is a pathogen recognition receptor for the viral pathogen-associated molecular pattern, double-stranded RNA. Upon recognition of dsRNA, the Oas2 activates Rnasel to cleave ssRNA. The Oas/Rnasel pathway triggers the RIG-I pathway and induce Ifnb production.
Entrez Gene
Summary This gene encodes a member of the 2-5A synthetase family, essential proteins involved in the innate immune response to viral infection. The encoded protein is induced by interferons and uses adenosine triphosphate in 2'-specific nucleotidyl transfer reactions to synthesize 2',5'-oligoadenylates (2-5As). These molecules activate latent RNase L, which results in viral RNA degradation and the inhibition of viral replication. The three known members of this gene family are located in a cluster on chromosome 12. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
This gene encodes a member of the 2-5A synthetase family, essential proteins involved in the innate immune response to viral infection. The encoded protein is induced by interferons and uses adenosine triphosphate in 2\'-specific nucleotidyl transfer reactions to synthesize 2\',5\'-oligoadenylates (2-5As). These molecules activate latent RNase L, which results in viral RNA degradation and the inhibition of viral replication. The three known members of this gene family are located in a cluster on chromosome 12. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:112978395-113011723
Strand Forward strand
Band q24.13
Transcripts
ENST00000342315 ENSP00000342278
ENST00000392583 ENSP00000376362
ENST00000449768 ENSP00000411763
ENST00000552756 ENSP00000446977
ENST00000551603 ENSP00000450307
ENST00000548941
ENST00000620097 ENSP00000483679
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 5 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0001730 2'-5'-oligoadenylate synthetase activity
GO:0003723 RNA binding
GO:0003725 double-stranded RNA binding
GO:0005524 ATP binding
GO:0008270 zinc ion binding
GO:0016740 transferase activity
GO:0016779 nucleotidyltransferase activity
GO:0046872 metal ion binding
Biological Process
GO:0006139 nucleobase-containing compound metabolic process
GO:0006164 purine nucleotide biosynthetic process
GO:0006401 RNA catabolic process
GO:0006486 protein glycosylation
GO:0006955 immune response
GO:0008152 metabolic process
GO:0009615 response to virus
GO:0018377 protein myristoylation
GO:0019221 cytokine-mediated signaling pathway
GO:0045087 innate immune response (InnateDB)
GO:0051607 defense response to virus
GO:0060333 interferon-gamma-mediated signaling pathway
GO:0060337 type I interferon signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005783 endoplasmic reticulum
GO:0005829 cytosol
GO:0016020 membrane
GO:0043231 intracellular membrane-bounded organelle
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000032690
View Gene Order
ENSBTAG00000014628
Not yet available
Pathways
NETPATH
REACTOME
REACT_25162
Interferon alpha/beta signaling pathway
REACT_25078
Interferon gamma signaling pathway
REACT_75790
Cytokine Signaling in Immune system pathway
REACT_25229
Interferon Signaling pathway
REACT_6900
Immune System pathway
KEGG
hsa05160
Hepatitis C pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.414332 Hs.620043
RefSeq NM_001032731 NM_002535 NM_016817
HUGO
OMIM
CCDS CCDS31906 CCDS41839 CCDS44982
HPRD 04518
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca