|Homo sapiens Gene: ARF6|
|Last Modified||2014-10-13 [Report errors or provide feedback]|
|Gene Name||ADP-ribosylation factor 6|
ADP-ribosylation factor 6
|Useful resources||Stemformatics EHFPI ImmGen|
ARF6 has a pivotal role in TLR9-mediated immune signaling by regulating the cellular uptake of CpG oligodeoxynucleotides.
ARF6 regulates LPS internalization and LPS-induced relocation of TICAM2 (TRAM), which is required for the MyD88-independent TLR4 signalling cascade.
|InnateDB Annotation from Orthologs|
[Mus musculus] Arf6 has a pivotal role in Tlr9-mediated immune signaling by regulating the cellular uptake of CpG oligodeoxynucleotides.
This gene encodes a member of the human ARF gene family, which is part of the RAS superfamily. The ARF genes encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking and as activators of phospholipase D. The product of this gene is localized to the plasma membrane, and regulates vesicular trafficking, remodelling of membrane lipids, and signaling pathways that lead to actin remodeling. A pseudogene of this gene is located on chromosome 7. [provided by RefSeq, Jul 2008]
|Genomic Location||Chromosome 14:49893092-49897054|
|Number of Interactions||
This gene and/or its encoded proteins are associated with 69 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Fc gamma R-mediated phagocytosis pathway
E-cadherin signaling in the nascent adherens junction
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
Class I PI3K signaling events
Alpha4 beta1 integrin signaling events
Arf6 downstream pathway
Stabilization and expansion of the E-cadherin adherens junction
Arf6 trafficking events
Arf6 signaling events
Posttranslational regulation of adherens junction stability and dissassembly
|UniProt Splice Variant|
|EMBL||AF047432 AF493885 AK313790 AY296206 BC002952 BC008918 CH471078 CR541964 M57763|
|GenPept||AAA90928 AAC39877 AAH08918 AAM12599 AAP50257 BAG36527 CAG46762 EAW65740|
|RNA Seq Atlas||382|