Homo sapiens Gene: ARF6
Summary
InnateDB Gene IDBG-5864.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ARF6
Gene Name ADP-ribosylation factor 6
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000165527
Encoded Proteins
ADP-ribosylation factor 6
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
ARF6 has a pivotal role in TLR9-mediated immune signaling by regulating the cellular uptake of CpG oligodeoxynucleotides.
ARF6 regulates LPS internalization and LPS-induced relocation of TICAM2 (TRAM), which is required for the MyD88-independent TLR4 signalling cascade.
InnateDB Annotation from Orthologs
Summary
[Mus musculus] Arf6 has a pivotal role in Tlr9-mediated immune signaling by regulating the cellular uptake of CpG oligodeoxynucleotides.
Entrez Gene
Summary This gene encodes a member of the human ARF gene family, which is part of the RAS superfamily. The ARF genes encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking and as activators of phospholipase D. The product of this gene is localized to the plasma membrane, and regulates vesicular trafficking, remodelling of membrane lipids, and signaling pathways that lead to actin remodeling. A pseudogene of this gene is located on chromosome 7. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:49893092-49897054
Strand Forward strand
Band q21.3
Transcripts
ENST00000298316 ENSP00000298316
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 69 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 69 [view]
Protein-Protein 69 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003924 GTPase activity
GO:0004871 signal transducer activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0019001 guanyl nucleotide binding
GO:0031683 G-protein beta/gamma-subunit complex binding
GO:0031996 thioesterase binding
Biological Process
GO:0001889 liver development
GO:0006184 GTP catabolic process
GO:0006886 intracellular protein transport
GO:0006928 cellular component movement
GO:0007049 cell cycle
GO:0007155 cell adhesion
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007264 small GTPase mediated signal transduction
GO:0015031 protein transport
GO:0016192 vesicle-mediated transport
GO:0030838 positive regulation of actin filament polymerization
GO:0030866 cortical actin cytoskeleton organization
GO:0031529 ruffle organization
GO:0033028 myeloid cell apoptotic process
GO:0034394 protein localization to cell surface
GO:0035020 regulation of Rac protein signal transduction
GO:0036010 protein localization to endosome
GO:0045087 innate immune response (InnateDB)
GO:0048261 negative regulation of receptor-mediated endocytosis
GO:0051301 cell division
GO:0051489 regulation of filopodium assembly
GO:0060998 regulation of dendritic spine development
GO:0090004 positive regulation of establishment of protein localization to plasma membrane
GO:0090162 establishment of epithelial cell polarity
GO:0097284 hepatocyte apoptotic process
Cellular Component
GO:0001726 ruffle
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005768 endosome
GO:0005769 early endosome
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0005938 cell cortex
GO:0016020 membrane
GO:0030139 endocytic vesicle
GO:0030496 midbody
GO:0031527 filopodium membrane
GO:0032154 cleavage furrow
GO:0055037 recycling endosome
GO:0055038 recycling endosome membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
Endocytosis pathway
Fc gamma R-mediated phagocytosis pathway
INOH
PID BIOCARTA
PID NCI
E-cadherin signaling in the nascent adherens junction
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
Class I PI3K signaling events
Plexin-D1 Signaling
Alpha4 beta1 integrin signaling events
Arf6 downstream pathway
Stabilization and expansion of the E-cadherin adherens junction
Arf6 trafficking events
Arf6 signaling events
Posttranslational regulation of adherens junction stability and dissassembly
Cross-References
SwissProt P62330
TrEMBL
UniProt Splice Variant
Entrez Gene 382
UniGene Hs.525330
RefSeq NM_001663
HUGO HGNC:659
OMIM 600464
CCDS CCDS9695
HPRD 02714
IMGT
EMBL AF047432 AF493885 AK313790 AY296206 BC002952 BC008918 CH471078 CR541964 M57763
GenPept AAA90928 AAC39877 AAH08918 AAM12599 AAP50257 BAG36527 CAG46762 EAW65740
RNA Seq Atlas 382