InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ARF6

Summary

InnateDB Gene

IDBG-5864.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ARF6

Gene Name

ADP-ribosylation factor 6

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000165527

Encoded Proteins

IDBP-5866

ADP-ribosylation factor 6

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 22170068

ARF6 has a pivotal role in TLR9-mediated immune signaling by regulating the cellular uptake of CpG oligodeoxynucleotides.

PMID 24297182

ARF6 regulates LPS internalization and LPS-induced relocation of TICAM2 (TRAM), which is required for the MyD88-independent TLR4 signalling cascade.

InnateDB Annotation from Orthologs

Summary

PMID 22170068

[Mus musculus] Arf6 has a pivotal role in Tlr9-mediated immune signaling by regulating the cellular uptake of CpG oligodeoxynucleotides.

Entrez Gene

Summary

This gene encodes a member of the human ARF gene family, which is part of the RAS superfamily. The ARF genes encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking and as activators of phospholipase D. The product of this gene is localized to the plasma membrane, and regulates vesicular trafficking, remodelling of membrane lipids, and signaling pathways that lead to actin remodeling. A pseudogene of this gene is located on chromosome 7. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 14:49893092-49897054

Strand

Forward strand

Band

q21.3

Transcripts

ENST00000298316

ENSP00000298316

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 69 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	69 [view]
Protein-Protein	69 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003924	GTPase activity
GO:0004871	signal transducer activity
GO:0005515	protein binding
GO:0005525	GTP binding
GO:0019001	guanyl nucleotide binding
GO:0031683	G-protein beta/gamma-subunit complex binding
GO:0031996	thioesterase binding

Biological Process

GO:0001889	liver development
GO:0006184	GTP catabolic process
GO:0006886	intracellular protein transport
GO:0006928	cellular component movement
GO:0007049	cell cycle
GO:0007155	cell adhesion
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007264	small GTPase mediated signal transduction
GO:0015031	protein transport
GO:0016192	vesicle-mediated transport
GO:0030838	positive regulation of actin filament polymerization
GO:0030866	cortical actin cytoskeleton organization
GO:0031529	ruffle organization
GO:0033028	myeloid cell apoptotic process
GO:0034394	protein localization to cell surface
GO:0035020	regulation of Rac protein signal transduction
GO:0036010	protein localization to endosome
GO:0045087	innate immune response (InnateDB)
GO:0048261	negative regulation of receptor-mediated endocytosis
GO:0051301	cell division
GO:0051489	regulation of filopodium assembly
GO:0060998	regulation of dendritic spine development
GO:0090004	positive regulation of establishment of protein localization to plasma membrane
GO:0090162	establishment of epithelial cell polarity
GO:0097284	hepatocyte apoptotic process

Cellular Component

GO:0001726	ruffle
GO:0005622	intracellular
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005768	endosome
GO:0005769	early endosome
GO:0005794	Golgi apparatus
GO:0005886	plasma membrane
GO:0005938	cell cortex
GO:0016020	membrane
GO:0030139	endocytic vesicle
GO:0030496	midbody
GO:0031527	filopodium membrane
GO:0032154	cleavage furrow
GO:0055037	recycling endosome
GO:0055038	recycling endosome membrane
GO:0070062	extracellular vesicular exosome