Version 5.4
Homo sapiens Gene: ANGPT2
Summary
InnateDB Gene IDBG-5893.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ANGPT2
Gene Name angiopoietin 2
Synonyms AGPT2; ANG2
Species Homo sapiens
Ensembl Gene ENSG00000091879
Encoded Proteins
IDBP-5897
angiopoietin 2
IDBP-5899
angiopoietin 2
IDBP-477017
angiopoietin 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is an antagonist of angiopoietin 1 (ANGPT1) and endothelial TEK tyrosine kinase (TIE-2, TEK). The encoded protein disrupts the vascular remodeling ability of ANGPT1 and may induce endothelial cell apoptosis. Three transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:6499651-6563409
Strand Reverse strand
Band p23.1
Transcripts
ENST00000325203 ENSP00000314897
ENST00000338312 ENSP00000343517
ENST00000523120 ENSP00000428023
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 12 [view]
Protein-Protein 11 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005102 receptor binding
GO:0005515 protein binding
GO:0030971 receptor tyrosine kinase binding
GO:0046872 metal ion binding
Biological Process
GO:0001525 angiogenesis
GO:0001666 response to hypoxia
GO:0007165 signal transduction
GO:0007281 germ cell development
GO:0007596 blood coagulation
GO:0009314 response to radiation
GO:0009612 response to mechanical stimulus
GO:0009749 response to glucose
GO:0010812 negative regulation of cell-substrate adhesion
GO:0014070 response to organic cyclic compound
GO:0014823 response to activity
GO:0016525 negative regulation of angiogenesis
GO:0031100 organ regeneration
GO:0043537 negative regulation of blood vessel endothelial cell migration
GO:0045766 positive regulation of angiogenesis
GO:0048014 Tie signaling pathway
GO:0048514 blood vessel morphogenesis
GO:0050900 leukocyte migration
GO:0050928 negative regulation of positive chemotaxis
GO:0060135 maternal process involved in female pregnancy
GO:0071363 cellular response to growth factor stimulus
GO:0072012 glomerulus vasculature development
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005886 plasma membrane
GO:0042995 cell projection
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000031465
View Gene Order
ENSBTAG00000011034
Not yet available
Pathways
NETPATH
REACTOME
REACT_12621
Tie2 Signaling pathway
REACT_12051
Cell surface interactions at the vascular wall pathway
REACT_604
Hemostasis pathway
KEGG
INOH
PID NCI
angiopoietinreceptor_pathway
Angiopoietin receptor Tie2-mediated signaling
Cross-References
SwissProt O15123
TrEMBL E7EVQ3 Q9H4C0 Q9HBP3
UniProt Splice Variant
Entrez Gene 285
UniGene Hs.583870
RefSeq NM_001118887 NM_001118888 NM_001147
HUGO HGNC:485
OMIM 601922
CCDS CCDS47761 CCDS5958
HPRD
IMGT
EMBL AB009865 AC018398 AF004327 AF187858 AF218015 AJ289781 AK290070 AY563557 BC126200 BC126202 BC143902 CH471153
GenPept AAB63190 AAF76526 AAG17257 AAI26201 AAI26203 AAI43903 AAT69979 BAA95590 BAF82759 CAC08180 EAW80474
RNA Seq Atlas 285

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca