Homo sapiens Gene: ANGPT2
Summary
InnateDB Gene IDBG-5893.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ANGPT2
Gene Name angiopoietin 2
Synonyms AGPT2; ANG2;
Species Homo sapiens
Ensembl Gene ENSG00000091879
Encoded Proteins
angiopoietin 2
angiopoietin 2
angiopoietin 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is an antagonist of angiopoietin 1 (ANGPT1) and endothelial TEK tyrosine kinase (TIE-2, TEK). The encoded protein disrupts the vascular remodeling ability of ANGPT1 and may induce endothelial cell apoptosis. Three transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:6499651-6563409
Strand Reverse strand
Band p23.1
Transcripts
ENST00000325203 ENSP00000314897
ENST00000338312 ENSP00000343517
ENST00000523120 ENSP00000428023
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 12 [view]
Protein-Protein 11 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005102 receptor binding
GO:0005515 protein binding
GO:0030971 receptor tyrosine kinase binding
GO:0046872 metal ion binding
Biological Process
GO:0001525 angiogenesis
GO:0001666 response to hypoxia
GO:0007165 signal transduction
GO:0007281 germ cell development
GO:0007596 blood coagulation
GO:0009314 response to radiation
GO:0009612 response to mechanical stimulus
GO:0009749 response to glucose
GO:0010812 negative regulation of cell-substrate adhesion
GO:0014070 response to organic cyclic compound
GO:0014823 response to activity
GO:0016525 negative regulation of angiogenesis
GO:0031100 organ regeneration
GO:0043537 negative regulation of blood vessel endothelial cell migration
GO:0045766 positive regulation of angiogenesis
GO:0048014 Tie signaling pathway
GO:0048514 blood vessel morphogenesis
GO:0050900 leukocyte migration
GO:0050928 negative regulation of positive chemotaxis
GO:0060135 maternal process involved in female pregnancy
GO:0071363 cellular response to growth factor stimulus
GO:0072012 glomerulus vasculature development
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005886 plasma membrane
GO:0042995 cell projection
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Tie2 Signaling pathway
Cell surface interactions at the vascular wall pathway
Hemostasis pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Angiopoietin receptor Tie2-mediated signaling
Cross-References
SwissProt
TrEMBL E7EVQ3 Q9H4C0
UniProt Splice Variant
Entrez Gene 285
UniGene Hs.583870
RefSeq NM_001147 NM_001118887 NM_001118888
HUGO HGNC:485
OMIM 601922
CCDS CCDS5958 CCDS47761
HPRD 03563
IMGT
EMBL AC018398 AJ289781 AY563557
GenPept AAT69979 CAC08180
RNA Seq Atlas 285