Version 5.4
Homo sapiens Gene: SLC1A5
Summary
InnateDB Gene IDBG-59011.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLC1A5
Gene Name solute carrier family 1 (neutral amino acid transporter), member 5
Synonyms AAAT; ASCT2; ATBO; M7V1; M7VS1; R16; RDRC
Species Homo sapiens
Ensembl Gene ENSG00000105281
Encoded Proteins
IDBP-382357
solute carrier family 1 (neutral amino acid transporter), member 5
IDBP-382358
solute carrier family 1 (neutral amino acid transporter), member 5
IDBP-598241
solute carrier family 1 (neutral amino acid transporter), member 5
IDBP-762618
IDBP-759820
IDBP-762090
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The SLC1A5 gene encodes a sodium-dependent neutral amino acid transporter that can act as a receptor for RD114/type D retrovirus (Larriba et al., 2001 [PubMed 11781704]).[supplied by OMIM, Jan 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:46774883-46788594
Strand Reverse strand
Band q13.32
Transcripts
ENST00000412532 ENSP00000397924
ENST00000434726 ENSP00000406532
ENST00000542575 ENSP00000444408
ENST00000594991 ENSP00000469265
ENST00000593713 ENSP00000468890
ENST00000598022 ENSP00000471626
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
Experimentally validated
Total 21 [view]
Protein-Protein 19 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0001618 virus receptor activity
GO:0004872 receptor activity
GO:0005515 protein binding
GO:0015171 amino acid transmembrane transporter activity
GO:0015175 neutral amino acid transmembrane transporter activity
GO:0015186 L-glutamine transmembrane transporter activity
GO:0015194 L-serine transmembrane transporter activity
GO:0017153 sodium:dicarboxylate symporter activity
Biological Process
GO:0003333 amino acid transmembrane transport
GO:0006811 ion transport
GO:0006835 dicarboxylic acid transport
GO:0006860 extracellular amino acid transport
GO:0006865 amino acid transport
GO:0006868 glutamine transport
GO:0009615 response to virus
GO:0015804 neutral amino acid transport
GO:0015825 L-serine transport
GO:0055085 transmembrane transport
Cellular Component
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0042470 melanosome
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000001918
View Gene Order
ENSBTAG00000013577
Not yet available
Pathways
NETPATH
REACTOME
REACT_13796
Amino acid transport across the plasma membrane pathway
REACT_19397
Transport of inorganic cations/anions and amino acids/oligopeptides pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_19118
SLC-mediated transmembrane transport pathway
KEGG
hsa04974
Protein digestion and absorption pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.631582
RefSeq NM_001145144 NM_001145145 NM_005628
HUGO
OMIM
CCDS CCDS12692 CCDS46125 CCDS46126
HPRD 00173
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca